用于单粒子成像的镧系掺杂上转换纳米颗粒。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-03-26 DOI:10.1002/cbic.202400942

Huan Ling, Wenrui Zhang, Yunxiang Zhang, Jie Shen, Qian Liu

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引用次数: 0

摘要

镧系掺杂上转换纳米粒子（UCNPs）由于其优异的光稳定性和最小的背景荧光，最近在单粒子成像（SPI）中显示出巨大的前景。然而，它们相对较暗的亮度对SPI应用的广泛采用构成了重大障碍。本文综述了UCNPs用于SPI的最新进展，重点介绍了在水环境中提高其亮度和减少猝灭效应的策略。此外，总结了利用UCNPs进行单粒子跟踪和超分辨率成像的最新进展，强调了它们在生物医学研究中的潜力。最后，综述概述了该领域当前的挑战和未来的方向。

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Lanthanide-Doped Upconversion Nanoparticles for Single-Particle Imaging.

Lanthanide-doped upconversion nanoparticles (UCNPs) have recently demonstrated great promise in single-particle imaging (SPI) due to their exceptional photostability and minimal background fluorescence. However, their limited brightness has posed a significant barrier to wider adoption in SPI applications. This review highlights recent advances in applying UCNPs for SPI, focusing on strategies to enhance their brightness and reduce quenching effects in aqueous environments. Additionally, it summarizes the latest progress in using UCNPs for single-particle tracking and super-resolution imaging, underscoring their potential in biomedical research. Finally, the review outlines current challenges and future directions in this field.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).