{"title":"智障儿童视网膜神经纤维层厚度、mak<e:1>厚度与黄斑体积的关系","authors":"Umut Karaaslan, Hatice Altun, Ayşegül Çömez","doi":"10.1002/jdn.70013","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>It was aimed to investigate retinal nerve fibre layer (RNFL) thickness, macular thickness and macular volume and the relationship between these parameters and the Weschler Intelligence Scale for Children (WISC-R) in children with intellectual disability (ID).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The study included 41 (27 male and 14 female) patients of ages 7–18 who were diagnosed with ID and 41 age- and sex-matched healthy individuals (24 male and 17 female). WISC-R intelligence test was applied with all the participants, and the parents were asked to fill out a Sociodemographic Data Form and the Strengths and Difficulties Questionnaire (SDQ). The RNFL, macular thickness and macular volume were examined by optical coherence tomography (OCT).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The RNFL was lower in all the quadrants (nasal, temporal, superior and inferior) in the patient group, but this thinness was not statistically significant in comparison to the control group. The left eye central macular and lest eye mean macular thicknesses were significantly lower in the patient group (respectively, <i>p</i> = 0.030, <i>p</i> = 0.048). Though not statistically significant, other all macular thickness and volume values were lower in the patient group in comparison to the control group. In the patient group, a weak negative correlation was observed between the performance subscore of the WISC-R and the RNFL values of the right eye inferior quadrant, as well as the left eye inferior and temporal quadrants (respectively, <i>r</i> = −0.329, <i>p</i> = 0.036; <i>r</i> = −0.308, <i>p</i> = 0.050; <i>r</i> = −0.309, <i>p</i> = 0.050). Additionally, a weak negative correlation was found between the total WISC-R scores and the RNFL values of the left eye temporal quadrant (<i>r</i> = −0.318, <i>p</i> = 0.043).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study suggests that macular thickness are reduced in ID patients but show no statistically significant changes in the RNFL. Lower macular thickness may potentially be linked to the brain abnormalities seen in ID, given the shared developmental origin of the retina and central nervous system. Further studies are needed to determine the potential application of OCT as a tool for diagnosing and monitoring the progression of this disease.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"85 2","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Retinal Nerve Fibre Layer Thickness, Maküler Thickness and Macular Volume in Children With Intellectual Disability\",\"authors\":\"Umut Karaaslan, Hatice Altun, Ayşegül Çömez\",\"doi\":\"10.1002/jdn.70013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>It was aimed to investigate retinal nerve fibre layer (RNFL) thickness, macular thickness and macular volume and the relationship between these parameters and the Weschler Intelligence Scale for Children (WISC-R) in children with intellectual disability (ID).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The study included 41 (27 male and 14 female) patients of ages 7–18 who were diagnosed with ID and 41 age- and sex-matched healthy individuals (24 male and 17 female). WISC-R intelligence test was applied with all the participants, and the parents were asked to fill out a Sociodemographic Data Form and the Strengths and Difficulties Questionnaire (SDQ). The RNFL, macular thickness and macular volume were examined by optical coherence tomography (OCT).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The RNFL was lower in all the quadrants (nasal, temporal, superior and inferior) in the patient group, but this thinness was not statistically significant in comparison to the control group. The left eye central macular and lest eye mean macular thicknesses were significantly lower in the patient group (respectively, <i>p</i> = 0.030, <i>p</i> = 0.048). Though not statistically significant, other all macular thickness and volume values were lower in the patient group in comparison to the control group. In the patient group, a weak negative correlation was observed between the performance subscore of the WISC-R and the RNFL values of the right eye inferior quadrant, as well as the left eye inferior and temporal quadrants (respectively, <i>r</i> = −0.329, <i>p</i> = 0.036; <i>r</i> = −0.308, <i>p</i> = 0.050; <i>r</i> = −0.309, <i>p</i> = 0.050). Additionally, a weak negative correlation was found between the total WISC-R scores and the RNFL values of the left eye temporal quadrant (<i>r</i> = −0.318, <i>p</i> = 0.043).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>This study suggests that macular thickness are reduced in ID patients but show no statistically significant changes in the RNFL. Lower macular thickness may potentially be linked to the brain abnormalities seen in ID, given the shared developmental origin of the retina and central nervous system. Further studies are needed to determine the potential application of OCT as a tool for diagnosing and monitoring the progression of this disease.</p>\\n </section>\\n </div>\",\"PeriodicalId\":13914,\"journal\":{\"name\":\"International Journal of Developmental Neuroscience\",\"volume\":\"85 2\",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Developmental Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70013\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70013","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Retinal Nerve Fibre Layer Thickness, Maküler Thickness and Macular Volume in Children With Intellectual Disability
Objective
It was aimed to investigate retinal nerve fibre layer (RNFL) thickness, macular thickness and macular volume and the relationship between these parameters and the Weschler Intelligence Scale for Children (WISC-R) in children with intellectual disability (ID).
Methods
The study included 41 (27 male and 14 female) patients of ages 7–18 who were diagnosed with ID and 41 age- and sex-matched healthy individuals (24 male and 17 female). WISC-R intelligence test was applied with all the participants, and the parents were asked to fill out a Sociodemographic Data Form and the Strengths and Difficulties Questionnaire (SDQ). The RNFL, macular thickness and macular volume were examined by optical coherence tomography (OCT).
Results
The RNFL was lower in all the quadrants (nasal, temporal, superior and inferior) in the patient group, but this thinness was not statistically significant in comparison to the control group. The left eye central macular and lest eye mean macular thicknesses were significantly lower in the patient group (respectively, p = 0.030, p = 0.048). Though not statistically significant, other all macular thickness and volume values were lower in the patient group in comparison to the control group. In the patient group, a weak negative correlation was observed between the performance subscore of the WISC-R and the RNFL values of the right eye inferior quadrant, as well as the left eye inferior and temporal quadrants (respectively, r = −0.329, p = 0.036; r = −0.308, p = 0.050; r = −0.309, p = 0.050). Additionally, a weak negative correlation was found between the total WISC-R scores and the RNFL values of the left eye temporal quadrant (r = −0.318, p = 0.043).
Conclusion
This study suggests that macular thickness are reduced in ID patients but show no statistically significant changes in the RNFL. Lower macular thickness may potentially be linked to the brain abnormalities seen in ID, given the shared developmental origin of the retina and central nervous system. Further studies are needed to determine the potential application of OCT as a tool for diagnosing and monitoring the progression of this disease.
期刊介绍：
International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
