绿色高效一锅合成1,3-二芳基-3-芳胺-丙烷-1-酮衍生物

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-03-26 DOI:10.1002/slct.202405766

Dhiraj D. Pawar, Aniket N. Timble, Mayuri B. Thorat, Krantisagar S. More, Yatin U. Gadkari

{"title":"绿色高效一锅合成1,3-二芳基-3-芳胺-丙烷-1-酮衍生物","authors":"Dhiraj D. Pawar, Aniket N. Timble, Mayuri B. Thorat, Krantisagar S. More, Yatin U. Gadkari","doi":"10.1002/slct.202405766","DOIUrl":null,"url":null,"abstract":"In this efficient approach, thiamine hydrochloride serves as an organocatalyst for the rapid synthesis of 1,3-diaryl-3-arylamino-propan-1-ones via a one-pot, multicomponent reaction (MCR). This protocol enables the production of β-amino carbonyl compounds using acetophenones with various substituted aromatic amines and aromatic aldehydes via a Mannich condensation reaction. The method offers several advantages, such as adhering to sustainable practices, following green chemistry principles, and providing an easy work-up process, yielding 1,3-diaryl-3-arylamino-propan-1-ones in moderate to excellent quantities.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Green and Efficient One-Pot Synthesis of 1,3-Diaryl-3-arylamino-propan-1-one Derivatives Using Thiamine Hydrochloride as a Catalyst\",\"authors\":\"Dhiraj D. Pawar, Aniket N. Timble, Mayuri B. Thorat, Krantisagar S. More, Yatin U. Gadkari\",\"doi\":\"10.1002/slct.202405766\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this efficient approach, thiamine hydrochloride serves as an organocatalyst for the rapid synthesis of 1,3-diaryl-3-arylamino-propan-1-ones via a one-pot, multicomponent reaction (MCR). This protocol enables the production of β-amino carbonyl compounds using acetophenones with various substituted aromatic amines and aromatic aldehydes via a Mannich condensation reaction. The method offers several advantages, such as adhering to sustainable practices, following green chemistry principles, and providing an easy work-up process, yielding 1,3-diaryl-3-arylamino-propan-1-ones in moderate to excellent quantities.\",\"PeriodicalId\":146,\"journal\":{\"name\":\"ChemistrySelect\",\"volume\":\"10 12\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemistrySelect\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/slct.202405766\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistrySelect","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/slct.202405766","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

在这种高效的方法中，硫胺素盐化物作为有机催化剂，通过一锅多组分反应（MCR）快速合成1,3-二芳基-3-芳基氨基-丙烷-1- 1。通过曼尼希缩合反应，利用苯乙酮与各种取代的芳香胺和芳香醛生产β-氨基羰基化合物。该方法有几个优点，如坚持可持续的做法，遵循绿色化学原则，并提供一个简单的加工过程，产生适量的1,3-二芳基-3-芳基氨基-丙烷-1- 1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Green and Efficient One-Pot Synthesis of 1,3-Diaryl-3-arylamino-propan-1-one Derivatives Using Thiamine Hydrochloride as a Catalyst

查看原文本刊更多论文

Green and Efficient One-Pot Synthesis of 1,3-Diaryl-3-arylamino-propan-1-one Derivatives Using Thiamine Hydrochloride as a Catalyst

In this efficient approach, thiamine hydrochloride serves as an organocatalyst for the rapid synthesis of 1,3-diaryl-3-arylamino-propan-1-ones via a one-pot, multicomponent reaction (MCR). This protocol enables the production of β-amino carbonyl compounds using acetophenones with various substituted aromatic amines and aromatic aldehydes via a Mannich condensation reaction. The method offers several advantages, such as adhering to sustainable practices, following green chemistry principles, and providing an easy work-up process, yielding 1,3-diaryl-3-arylamino-propan-1-ones in moderate to excellent quantities.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.