取代3-噻吩- 3h -呋喃-2-酮与取代肼和取代肼反应产物的合成及抗菌活性研究

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI:10.1134/S1070363224607816

D. V. Lipin, N. A. Pulina, V. V. Novikova, R. R. Makhmudov, N. V. Zhekina, V. M. Shadrin

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引用次数: 0

摘要

提出了一种以取代3-噻吩基氨基- 3h -呋喃-2-酮为原料，与各种肼和肼类化合物合成新的生物活性化合物的方法。考虑了在存在一种肼或肼当量或其过量的情况下进行合成。所得化合物对白色念珠菌NCTC 885-653、金黄色葡萄球菌ATCC 6538-P和大肠杆菌ATCC 25922具有明显的抗菌活性。所得化合物的急性毒性（LD50）为1500 mg/kg，属于几乎无毒的化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Study of Antimicrobial Activity of Reaction Products of Substituted 3-Thienylimino-3H-furan-2-ones with Substituted Hydrazines and Hydrazides

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Synthesis and Study of Antimicrobial Activity of Reaction Products of Substituted 3-Thienylimino-3H-furan-2-ones with Substituted Hydrazines and Hydrazides

A method was proposed for the synthesis of new biologically active compounds based on substituted 3-thienylimino-3H-furan-2-ones with various hydrazines and hydrazides. Synthesis in the presence of one equivalent of hydrazine or hydrazide or their excess was considered. The obtained compounds were found to possess pronounced antimicrobial activity against strains of Candida albicans NCTC 885-653, Staphylococcus aureus ATCC 6538-P, and Escherichia coli ATCC 25922. The acute toxicity (LD₅₀) of the obtained compounds is >1500 mg/kg and they belong to practically nontoxic compounds.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.