在圈养雪豹(Panthera uncia)中爆发的犬冠状病毒2型暴发表明,猫科动物可能是冠状病毒的混合容器

Ximena A. Olarte-Castillo , Abigail B. Schlecht , Paul P. Calle , Gary R. Whittaker
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引用次数: 0

摘要

目的甲型冠状病毒-1由一系列高度重组的病毒组成,包括猫冠状病毒(FCoV) 2型(FCoV-2)、FCoV 1型的重组基因型和犬冠状病毒2型(CCoV-2)。为了了解新的重组变异的起源,鉴定对多种甲型冠状病毒敏感的宿主是至关重要的。FCoV-2和CCoV-2的受体是氨基肽酶N (APN),家猫的APN允许FCoV-2和CCoV-2进入。然而,CCoV-2的自然感染仅在犬科动物中报道。方法对一起圈养雪豹(Panthera uncia) CCoV-2疫情进行调查。本研究对亚洲5种野生野种APN的遗传多样性进行了评估,以评估它们对CCoV-2和FCoV-2的易感性。结果从雪豹粪便中获得了冠状病毒-2全基因组序列。它与在美国和欧洲家养狗中报道的致病性变异密切相关。野猫的APN与家猫的APN高度相似。结论本研究首次提供了野地感染CCoV-2的遗传证据,并预测野生野地可能对FCoV-2和CCoV-2易感。因此,猫科动物可能在重组甲型冠状病毒的出现中发挥核心作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An outbreak of canine coronavirus type 2 in captive snow leopards (Panthera uncia) demonstrates a possible role for felids as mixing vessels for alphacoronaviruses

Objectives

Alphacoronavirus-1 comprises a set of viruses that are highly recombinogenic, including feline coronavirus (FCoV) type 2 (FCoV-2), a recombinant genotype of FCoV type 1, and canine coronavirus type 2 (CCoV-2). To understand the origin of novel recombinant variants, it is crucial to identify hosts susceptible to multiple alphacoronaviruses. The receptor for FCoV-2 and CCoV-2 is aminopeptidase N (APN), with the APN of the domestic cat allowing entry of FCoV-2 and CCoV-2. However, natural infection with CCoV-2 has been reported exclusively in canids.

Methods

We investigated an outbreak of CCoV-2 in captive snow leopards (Panthera uncia). We assessed the genetic diversity of the APN of five wild Asian felid species to evaluate their susceptibility to CCoV-2 and FCoV-2.

Results

The whole genome of CCoV-2 was sequenced from the feces of the snow leopards. It is closely related to pathogenic variants reported in domestic dogs in the United States and Europe. The APN of the wild felids is highly similar to the APN of the domestic cat.

Conclusions

This study provides the first genetic evidence of CCoV-2 infection in a felid and predicts that wild felids may be susceptible to FCoV-2 and CCoV-2. Therefore, felids may play a central role in the emergence of recombinant alphacoronavirus.
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