Corollary discharge signals during production are domain general: An intracerebral EEG case study with a professional musician

As measured by event-related potentials, self-produced sounds elicit an overall reduced response in the auditory cortex compared to identical externally presented stimuli. This study examines this modulatory effect with high-precision recordings in naturalistic settings and explores whether it is domain-general across speech or music. Using stereotactic EEG with a professional musician undergoing presurgical epilepsy evaluation, we recorded auditory cortical activity during music and speech production and perception tasks. Compared to externally presented sounds, self-produced sounds induce modulation of activity in the auditory cortex which vary across frequency and spatial location but is consistent across cognitive domains (speech/music) and different stimuli. Self-produced music and speech were associated with widespread low-frequency (4–8 Hz) suppression, mid-frequency (8–80 Hz) enhancement, and decreased encoding of acoustic features. These findings reveal the domain-general nature of motor-driven corollary discharge modulatory signals and their frequency-specific effects in auditory regions.