小分子胶选择性地限制去泛素化酶活性和炎症信号

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-03-25 DOI:10.1038/s41594-025-01518-4

引用次数: 0

摘要

一类新的小分子“胶”通过将BRISC去泛素化酶复合物稳定在非活性二聚体构象中来选择性地抑制它。这些化合物通过阻止干扰素受体的去泛素化来减少炎症信号，从而为治疗I型干扰素驱动的疾病提供了一条有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Small-molecule glues selectively restrict deubiquitylase activity and inflammatory signaling

查看原文本刊更多论文

Small-molecule glues selectively restrict deubiquitylase activity and inflammatory signaling

A new class of small molecular ‘glues’ selectively inhibit the BRISC deubiquitylase complex by stabilizing it in an inactive dimeric conformation. These compounds reduce inflammatory signaling by preventing deubiquitylation of an interferon receptor, and thereby offer a promising avenue for the treatment of type I interferon-driven diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.