{"title":"小分子胶选择性地限制去泛素化酶活性和炎症信号","authors":"","doi":"10.1038/s41594-025-01518-4","DOIUrl":null,"url":null,"abstract":"A new class of small molecular ‘glues’ selectively inhibit the BRISC deubiquitylase complex by stabilizing it in an inactive dimeric conformation. These compounds reduce inflammatory signaling by preventing deubiquitylation of an interferon receptor, and thereby offer a promising avenue for the treatment of type I interferon-driven diseases.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"93 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Small-molecule glues selectively restrict deubiquitylase activity and inflammatory signaling\",\"authors\":\"\",\"doi\":\"10.1038/s41594-025-01518-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A new class of small molecular ‘glues’ selectively inhibit the BRISC deubiquitylase complex by stabilizing it in an inactive dimeric conformation. These compounds reduce inflammatory signaling by preventing deubiquitylation of an interferon receptor, and thereby offer a promising avenue for the treatment of type I interferon-driven diseases.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"93 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01518-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01518-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Small-molecule glues selectively restrict deubiquitylase activity and inflammatory signaling
A new class of small molecular ‘glues’ selectively inhibit the BRISC deubiquitylase complex by stabilizing it in an inactive dimeric conformation. These compounds reduce inflammatory signaling by preventing deubiquitylation of an interferon receptor, and thereby offer a promising avenue for the treatment of type I interferon-driven diseases.
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