Charcot骨关节病:早期检测新生物标志物近期研究的综合分析。

Effrosyni Blathra, Ioanna A Anastasiou, Ioanna Eleftheriadou, Nikolaos Papanas, Nicholas Tentolouris
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引用次数: 0

摘要

Charcot骨关节病(CO)是一种罕见且常被误诊的糖尿病并发症。延误诊断可能对患者的肢体和生命造成严重后果。其诊断首先是基于临床怀疑,主要是临床,并通过影像学检查,如磁共振成像证实。目前尚未发现用于早期检测和治疗的特异性生物标志物。对一氧化碳发病机制的理解和对参与其中的分子的测量可以朝着这个方向发展。本综述的目的是总结/描述目前在CO患者中测量生物标志物的最新研究。共聚焦角膜显微镜(CCM),炎症标志物包括IL-1, IL-6和TNF-a,骨代谢标志物如RANK, RANKL, OPG,晚期糖基化终产物(AGEs)和骨矿物质密度(BMD)是近20年来大量研究中最受欢迎的指标,CO患者与非charcot组相比,上述指标水平存在显著差异。未来和更大规模的研究可能会导致发现新的生物标志物,在早期阶段迅速检测到这种特殊实体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Charcot Osteoarthropathy: A Comprehensive Analysis of Recent Research on Novel Biomarkers for Early Detection.

Charcot osteoarthropathy (CO) is an unusual and frequently misdiagnosed complication of diabetes mellitus. The delayed diagnosis can have severe consequences for patients' limb and life. Its diagnosis is based firstly in its clinical suspicion, is mainly clinical and is confirmed by imaging tests, like magnetic resorance imaging. Specific biomarkers for its early detection and therapy have not been found yet. The understanding of CO pathogenesis and measurement of molecules involved in this can head to this direction. The purpose of this review is to summarize/describe the most current studies measuring biomarkers in people with CO. Confocal corneal microscopy (CCM), inflammatory markers including IL-1, IL-6 and TNF-a, bone metabolism markers like RANK, RANKL, OPG, advanced glycation end products (AGEs) and bone mineral density (BMD) were among the most popular ones included in a large number of studies of the last 20 years and people with CO have significant different levels of the above comparing to non-Charcot groups. Future and larger studies can lead to the discovery of novel biomarkers of the prompt detection of this special entity at an early stage.

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