IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Aline Marcadenti, Josefina Bressan, Annie Seixas Bello Moreira, Rachel Helena V Machado, Renato Hideo N Santos, Cristiane Kovacs Amaral, Marcelo Macedo Rogero, Vinícius Cooper Capetini, Angela C Bersch-Ferreira
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引用次数: 0

摘要

研究目的本研究旨在评估巴西心血管保护营养计划(BALANCE 计划)在三年随访期内对接受心血管二级预防的患者血浆中各种脂蛋白(A-I、A-II、B、C-II、C-III 和 E)和血脂生物标志物水平的影响:这项探索性分析包括 276 名年龄在 45 岁或以上、在过去十年中曾患心血管疾病的患者。参与者被随机分配到两组中的一组,并接受为期三年的监测:"平衡计划 "组(干预组;人数=123)和对照组(常规营养建议;人数=153)。在基线和三年随访期间,对临床和生活方式数据、人体测量、食物摄入量、血浆脂蛋白和血脂概况进行了评估。干预措施的坚持情况通过 "BALANCE膳食指数 "进行测量:结果:在随访期结束时,干预组的依从性明显提高(BALANCE-对照组的平均差异[95% CI]:2.09分 [-0.19; 4.37]),这主要是由于水果、蔬菜、豆类和低脂乳制品的摄入量增加。在整个研究过程中,各组之间的血浆载脂蛋白水平没有明显差异。不过,与对照组相比,"平衡 "组的总胆固醇和非高密度脂蛋白胆固醇水平明显下降(干预组与对照组的平均差异[95% CI]:分别为-9.95 mg/dL [-18.5; -1.39] 和-8.86 mg/dL [-17.53; -0.2]):经过三年的干预,尽管更多的人加入了 "平衡计划",但血浆载脂蛋白浓度或总体血脂生物标志物没有发生显著变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention.

Objective: This study aimed to evaluate the impact of the Brazilian Cardioprotective Nutrition Program (BALANCE Program) on the plasma levels of various apolipoproteins (A-I, A-II, B, C-II, C-III, and E) and lipid biomarkers over a three-year follow-up period in individuals undergoing secondary cardiovascular prevention.

Subjects and methods: This exploratory analysis included 276 patients aged 45 years or older with a history of cardiovascular disease within the preceding decade. Participants were randomly assigned to one of two groups and monitored over three years: the BALANCE Program group (intervention group; n = 123) and the control (conventional nutritional advice; n = 153). Assessments of clinical and lifestyle data, anthropometry, food intake, plasma apolipoproteins, and lipid profiles were conducted at baseline and at the 3-year follow-up. Intervention adherence was measured utilizing the BALANCE dietary index.

Results: By the end of the follow-up period, adherence was significantly higher in the intervention group (mean difference BALANCE-control [95% CI]: 2.09 points [-0.19; 4.37]), mainly due to increased consumption of fruits, vegetables, legumes, and low-fat dairy products. There were no significant differences in plasma apolipoprotein levels between the groups throughout the study. Nevertheless, significant reductions were observed in the total cholesterol and non-HDL cholesterol levels in the BALANCE group compared to the control group (mean difference intervention-control [95% CI]: -9.95 mg/dL [-18.5; -1.39] and -8.86 mg/dL [-17.53; -0.2], respectively).

Conclusion: Following three years of intervention, despite higher adherence to the BALANCE Program, there were no significant changes in plasma apolipoprotein concentrations or overall lipid biomarkers.

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来源期刊
Archives of Endocrinology Metabolism
Archives of Endocrinology Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.90
自引率
5.90%
发文量
107
审稿时长
7 weeks
期刊介绍: The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association. Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com. From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese. The journal is published six times a year, with one issue every two months.
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