Suhaib Abdulfattah, Iqra Nadeem, Yashaswi Parikh, Sami Shaikh, Sonam Saxena, Aznive Aghababian, Katherine Fischer, Sameer Mittal, Arun K Srinivasan, Aseem R Shukla
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引用次数: 0
摘要
导言:虽然大而无症状的泌尿道异常(UA)常常导致手术切除,但泌尿道恶性肿瘤却很少见,因此没有必要进行预防性切除。我们假设,在儿科人群中,感染性泌尿道畸形是导致手术干预的主要病因:我们对 2012 年 7 月至 2021 年 12 月期间在泌尿科门诊接受评估的尿道炎患者进行了回顾性鉴定。纳入标准包括年龄小于 18 周岁且经超声检查(US)确诊为尿崩症的患者。排除标准包括:超声波检查确诊为临床模仿者的患者、由普通儿科手术部门进行切除术的患者,或作为其他泌尿外科手术的一部分同时进行切除术的患者:我们共发现了 78 名尿道炎患者。结果:我们共发现 78 例尿道炎患者,其中 35 例(44.9%)接受了切除术。观察组患者更年轻(5个月 vs. 73个月,p=0.002),更有可能无症状(65.1% vs. 85.7%,p=0.038),更有可能在US检查中将UA定性为 "残余"(72.1% vs. 48.6%,p=0.034)。单变量分析显示,感染性或有症状的尿道炎,或在 US 上表现为充血、囊肿或憩室的尿道炎更有可能被切除。多变量分析显示,"泌尿道囊肿 "分类(P=0.008)和感染性表现(P=0.046)的患者更有可能接受手术治疗。切除手术通过腹腔镜(80.0%)或机器人(11.4%)完成。没有切除的UA可疑恶性:我们研究了一大批患有泌尿系结石的儿科患者,发现与其他因素相比,发病时出现感染症状以及根据尿路造影被归类为 "泌尿系囊肿 "的患者更有可能接受手术切除。
Management of urachal anomalies in children: insights from a retrospective cohort study.
Introduction: While large and symptomatic urachal anomalies (UAs) often lead to surgical excision, urachal malignancy is rare, rendering prophylactic excision unwarranted. We hypothesize that in the pediatric population, the presentation of an infected UA is the predominant etiology leading to surgical intervention.
Methods: We retrospectively identified patients with UA from July 2012 to December 2021 evaluated in our urology outpatient. Inclusion criteria included patients ≤18 years old and confirmation of UA on ultrasound (US). Exclusion criteria were patients diagnosed with clinical mimickers on US, excision by general pediatric surgery service, or excision done concomitantly as part of another urological procedure.
Results: We identified a total of 78 patients with UA. Of those, 35 (44.9%) underwent excision. The observation cohort was younger (5 months vs. 73 months, p=0.002), more likely to be asymptomatic (65.1% vs. 85.7%, p=0.038), and more likely to have UA characterized as a 'remnant' on US (72.1% vs. 48.6%, p=0.034). Univariate analysis showed that infected or symptomatic UA, or those characterized as hyperemic, cystic, or as a diverticulum on US were more likely to be excised. Multivariable analysis shows that patients with a 'urachal cyst' classification (p=0.008) and infectious presentation (p=0.046) were more likely to undergo surgical intervention. Excision was accomplished laparoscopically (80.0%) or robotically (11.4%). No excised UA was suspicious for malignancy.
Conclusion: We present a large pediatric cohort with UA and found that infectious symptoms at presentation and those classified as 'urachal cyst' based on US were more likely to prompt surgical excision as compared with other factors.