Gennaro Musella, Martina Coppini, Fábio França Vieira E Silva, Giuseppina Campisi, Mario Pérez-Sayáns, Vito Carlo Alberto Caponio, Alejandro I Lorenzo-Pouso
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引用次数: 0
摘要
背景：肿瘤间质比（TSR）已被认为是多种癌症的重要预后因素。本系统综述评估了TSR在头颈部鳞状细胞癌（HNSCC）中的作用及其与患者预后的关系，如总生存期（OS）、无病生存期（DFS）、疾病特异性生存期（DSS）和淋巴结转移（LNM）。方法：综合检索Scopus、Embase、PubMed、Web of Science。纳入了19项研究。逐步进行数据提取和质量评估，并进行meta分析。所有的研究都使用苏木精和伊红染色来评估组织样本的TSR。荟萃分析的重点是TSR对OS、DFS、DSS和LNM的影响，提供了具有相应置信区间（ci）的合并风险比（hr）和优势比（ORs）。结果：荟萃分析显示TSR与OS之间存在显著相关性（HR 1.99, 95% CI 1.71-2.32, p）。结论：TSR可以有效识别高危患者，是一种可靠的预后标志物，可以很容易地纳入HNSCC的常规病理实践。
Tumor-Stroma Ratio in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Background: Tumor-stroma ratio (TSR) has been recognized as a significant prognostic factor in various cancers. This systematic review evaluates the role of TSR in head and neck squamous cell carcinoma (HNSCC) and its association with patient outcomes such as overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and lymph node metastasis (LNM).
Methods: A comprehensive search was conducted across Scopus, Embase, PubMed, and Web of Science. Nineteen studies were included. Data extraction and quality assessment were performed progressively, with meta-analyses. All studies assessed TSR using hematoxylin and eosin staining of tissue samples. The meta-analyses focused on the impact of TSR on OS, DFS, DSS, and LNM, providing pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding confidence intervals (CIs).
Results: Meta-analysis revealed a significant association between TSR and OS (HR 1.99, 95% CI 1.71-2.32, p < 0.001), DFS (HR 2.07, 95% CI 1.80-2.39, p < 0.001), DSS (HR 2.33, 95% CI 1.95-2.78, p < 0.001), and LNM (OR 1.76, 95% CI 1.15-2.70, p = 0.01). Minimal to low heterogeneity was detected among studies, and no publication bias was observed.
Conclusions: TSR can effectively identify high-risk patients, being a reliable prognostic marker that could be readily integrated into routine pathology practice for HNSCC.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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