儿童1型糖尿病患者细胞外(血清)基质金属蛋白酶水平与糖尿病酮症酸中毒和脑水肿的关系

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Qingbo Xu, Yu Yang, Qiang Huang, Liling Xie, Yaqin Feng, Li Yang
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引用次数: 0

摘要

背景:儿童1型糖尿病(T1DM)与糖尿病酮症酸中毒(DKA)等急性并发症以及糖尿病酮症酸中毒相关脑水肿(DKACE)的严重风险相关。基质金属蛋白酶(MMPs)与炎症和组织重塑有关,可能导致这些并发症。本研究探讨了MMPs作为DKA和DKACE儿童T1DM患者生物标志物的作用。方法:我们在江西省儿童医院进行了系统的横断面研究,纳入56例T1DM患儿,分为三组:无并发症的T1DM组、DKA组和DKACE组。ELISA法检测血清中MMP-2、MMP-3、MMP-9的水平。统计分析评估了MMPs、葡萄糖代谢和炎症标志物之间的相关性,评估了潜在的生物标志物在疾病表征中的效用。结果:与T1DM和DKA组相比,DKACE组的MMP-3和MMP-9水平显著升高,与pH和碳酸氢盐水平降低有很强的相关性(p < 0.001)。MMP-2水平在DKACE中降低,与pH和碳酸氢盐水平呈正相关。临床后改善分析显示,DKA组和DKACE组之间MMP水平无显著差异,表明治疗后稳定,无论初始酸中毒严重程度如何。结论:MMP-3和MMP-9在DKACE中不同的升高模式突出了它们作为识别和监测严重DKA并发症的生物标志物的潜力。研究结果表明,这些酶在脑水肿病理生理中起着重要作用,使它们成为未来治疗干预的可行目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extracellular(Serum) Levels of Matrix Metalloproteinases in Pediatric Type 1 Diabetes Mellitus and Association with Diabetic Ketoacidosis and Cerebral Edema.

Background: Type 1 diabetes mellitus (T1DM) in children is associated with acute complications such as diabetic ketoacidosis (DKA) and the severe risk of diabetic ketoacidosis-related cerebral edema (DKACE). Matrix metalloproteinases (MMPs) are implicated in inflammation and tissue remodeling, potentially contributing to these complications. This study explores the role of MMPs as biomarkers in pediatric T1DM patients with DKA and DKACE.

Methods: We conducted a systematic cross-sectional study at Jiangxi Children's Hospital, enrolling 56 pediatric patients with T1DM, categorized into three groups: T1DM without complications, DKA, and DKACE. Serum levels of MMP-2, MMP-3, and MMP-9 were measured through ELISA. Statistical analyses assessed correlations between MMPs, glucose metabolism, and inflammatory markers, evaluating potential biomarker utility in disease characterization.

Results: MMP-3 and MMP-9 levels were significantly elevated in the DKACE group compared to the T1DM and DKA groups, exhibiting strong correlations with decreased pH and bicarbonate levels (both p < 0.001). MMP-2 levels were reduced in DKACE, correlating positively with pH and bicarbonate levels. Post-clinical improvement analyses demonstrated no significant differences in MMP levels between DKA and DKACE groups, suggesting stabilization post-treatment regardless of initial acidosis severity.

Conclusion: The distinct patterns of MMP-3 and MMP-9 elevations in DKACE highlight their potential as biomarkers for identifying and monitoring severe DKA complications. The findings suggest these enzymes play a significant role in cerebral edema pathophysiology, making them viable targets for future therapeutic interventions.

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来源期刊
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
5.90
自引率
6.10%
发文量
431
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.
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