皮杉醇通过激活MAPKs促进人牙周韧带细胞成骨分化。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-21 DOI:10.1093/bbb/zbaf040

Hiromu Morimoto, Hirofumi Inoue, Kotone Date, Shinpei Kawakami, Sadao Mori, Hiroko Maruki-Uchida, Nobuyuki Takahashi, Mariko Uehara

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引用次数: 0

摘要

研究了皮杉醇对人牙周韧带成纤维细胞成骨分化的影响。用皮杉醇处理可增加碱性磷酸酶活性和成骨分化基因分子（骨钙素和Runx2），但用丝裂原活化蛋白激酶（MAPK）抑制剂（PD098059或SB203580）可减弱这种活性。我们的数据表明，皮杉酚通过激活MAPKs促进HPLFs的成骨分化。

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Piceatannol promotes the osteogenic differentiation of human periodontal ligament cells through MAPKs activation.

We investigated the effects of piceatannol on the osteogenic differentiation of human periodontal ligament fibroblasts (HPLFs). Treatment with piceatannol increased alkaline phosphatase activity and osteogenic differentiation gene molecules (Osteocalcin and Runx2), but this was attenuated by mitogen-activated protein kinase (MAPK) inhibitors (PD098059 or SB203580). Our data suggest that piceatannol promotes osteogenic differentiation of HPLFs by activating MAPKs.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).