羧甲基纤维素微凝胶作为多功能载体固定化诱导型NO合成酶抑制剂和活化剂

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-03-25 DOI:10.1007/s11172-025-4520-y

A. S. Zolotova, M. A. Orlova, V. V. Spiridonov, T. P. Trofimova, A. Yu. Lupatov, A. A. Yaroslavov, S. N. Kalmykov

{"title":"羧甲基纤维素微凝胶作为多功能载体固定化诱导型NO合成酶抑制剂和活化剂","authors":"A. S. Zolotova, M. A. Orlova, V. V. Spiridonov, T. P. Trofimova, A. Yu. Lupatov, A. A. Yaroslavov, S. N. Kalmykov","doi":"10.1007/s11172-025-4520-y","DOIUrl":null,"url":null,"abstract":"<div>Three-component (ternary) microgels based on carboxymethylcellulose and copper(ii) ions with the immobilized inhibitor of inducible NO synthase (N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide), as well as the activator of this enzyme (N-(4-isopropylphenyl)-N-(1-iminoethyl)piperidine-1-carbothioamide hydrobromide) were prepared. The hydrodynamic and electrokinetic characteristics of the microgels were studied and demonstrate an optimal size and high colloidal stability in both aqueous and physiological environments. The synthesized ternary microgels are characterized by high cytotoxicity causing apoptosis of leukemic Jurkat cells.</div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 1","pages":"252 - 255"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microgels based on carboxymethylcellulose as multifunctional carriers for immobilization of inhibitor and activator of inducible NO synthase\",\"authors\":\"A. S. Zolotova, M. A. Orlova, V. V. Spiridonov, T. P. Trofimova, A. Yu. Lupatov, A. A. Yaroslavov, S. N. Kalmykov\",\"doi\":\"10.1007/s11172-025-4520-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>Three-component (ternary) microgels based on carboxymethylcellulose and copper(ii) ions with the immobilized inhibitor of inducible NO synthase (N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide), as well as the activator of this enzyme (N-(4-isopropylphenyl)-N-(1-iminoethyl)piperidine-1-carbothioamide hydrobromide) were prepared. The hydrodynamic and electrokinetic characteristics of the microgels were studied and demonstrate an optimal size and high colloidal stability in both aqueous and physiological environments. The synthesized ternary microgels are characterized by high cytotoxicity causing apoptosis of leukemic Jurkat cells.</div>\",\"PeriodicalId\":756,\"journal\":{\"name\":\"Russian Chemical Bulletin\",\"volume\":\"74 1\",\"pages\":\"252 - 255\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11172-025-4520-y\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11172-025-4520-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

以羧甲基纤维素和铜（ii）离子为基础，制备了固定化NO合成酶抑制剂(N-（5,6-二氢- 4h -1,3-噻嗪-2-基）苯酰胺和该酶活化剂（N-（4-异丙基苯基）-N-（1-亚氨基乙基）哌啶-1-碳硫酰胺氢溴化物）的三组分（三元）微凝胶。对微凝胶的水动力学和电动力学特性进行了研究，结果表明微凝胶在水环境和生理环境中均具有最佳尺寸和较高的胶体稳定性。合成的三元微凝胶具有引起白血病Jurkat细胞凋亡的高细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Microgels based on carboxymethylcellulose as multifunctional carriers for immobilization of inhibitor and activator of inducible NO synthase

Three-component (ternary) microgels based on carboxymethylcellulose and copper(ii) ions with the immobilized inhibitor of inducible NO synthase (N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide), as well as the activator of this enzyme (N-(4-isopropylphenyl)-N-(1-iminoethyl)piperidine-1-carbothioamide hydrobromide) were prepared. The hydrodynamic and electrokinetic characteristics of the microgels were studied and demonstrate an optimal size and high colloidal stability in both aqueous and physiological environments. The synthesized ternary microgels are characterized by high cytotoxicity causing apoptosis of leukemic Jurkat cells.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.