{"title":"血浆 GFAP、NfL 和 p-tau181 水平作为中国成人痴呆症的早期生物标志物:深圳社区队列研究","authors":"Chunhua Liang, Xueqin Yan, Jing Tian, Yunzhu Yang, Xiaohua Xiao, Yaohui Huang, Tianfu Wang","doi":"10.1007/s40520-025-03001-y","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Although blood-based biomarkers can be used to detect early Alzheimer’s disease (AD), population differences affect their clinical value in early diagnosis of the disease spectrum.</p><h3>Aims</h3><p>To examine the potential of plasma biomarkers to detect different stages along the AD continuum in a Chinese population.</p><h3>Methods</h3><p>We enrolled 113 adults from the Shenzhen community (53 cognitively unimpaired [CU], 45 with mild cognitive impairment [MCI], and 15 with AD). We used the single-molecule array technique to detect the levels of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated-tau181 (p-tau181), and performed <i>APOE</i> genotyping. We assessed the association between plasma biomarkers and cognitive scores, and used receiver operating characteristic curves to measure performance for early AD diagnosis.</p><h3>Results</h3><p>The plasma GFAP, NfL, and p-tau181 levels increased significantly in AD and were slightly higher in MCI than in CU (GFAP <i>p</i> = 0.811, NfL <i>p</i> = 0.909, p-tau181 <i>p</i> = 0.696). The plasma GFAP and p-tau181 levels negatively correlated with cognitive scores. Blood markers demonstrated higher performance in identifying AD than CU or MCI. Plasma p-tau181 displayed the highest diagnostic value for AD. Predictions of cognitive impairment were more robust when blood markers were combined with clinical indicators for AD (age, sex, body mass index, years of education, and <i>APOE ε4</i> carrier status).</p><h3>Discussion</h3><p>The expression of plasma GFAP, NfL, and p-tau181 increased in the AD continuum. Importantly, plasma p-tau181 could identify individuals with AD from the general population, with superior predictive performance when combined with age or sex.</p><h3>Conclusions</h3><p>Plasma biomarkers are useful screening indicators for early AD in Chinese adults.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03001-y.pdf","citationCount":"0","resultStr":"{\"title\":\"Plasma GFAP, NfL, and p-tau181 levels as early biomarkers of dementia in Chinese adults: Shenzhen community cohort study\",\"authors\":\"Chunhua Liang, Xueqin Yan, Jing Tian, Yunzhu Yang, Xiaohua Xiao, Yaohui Huang, Tianfu Wang\",\"doi\":\"10.1007/s40520-025-03001-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Although blood-based biomarkers can be used to detect early Alzheimer’s disease (AD), population differences affect their clinical value in early diagnosis of the disease spectrum.</p><h3>Aims</h3><p>To examine the potential of plasma biomarkers to detect different stages along the AD continuum in a Chinese population.</p><h3>Methods</h3><p>We enrolled 113 adults from the Shenzhen community (53 cognitively unimpaired [CU], 45 with mild cognitive impairment [MCI], and 15 with AD). We used the single-molecule array technique to detect the levels of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated-tau181 (p-tau181), and performed <i>APOE</i> genotyping. We assessed the association between plasma biomarkers and cognitive scores, and used receiver operating characteristic curves to measure performance for early AD diagnosis.</p><h3>Results</h3><p>The plasma GFAP, NfL, and p-tau181 levels increased significantly in AD and were slightly higher in MCI than in CU (GFAP <i>p</i> = 0.811, NfL <i>p</i> = 0.909, p-tau181 <i>p</i> = 0.696). The plasma GFAP and p-tau181 levels negatively correlated with cognitive scores. Blood markers demonstrated higher performance in identifying AD than CU or MCI. Plasma p-tau181 displayed the highest diagnostic value for AD. Predictions of cognitive impairment were more robust when blood markers were combined with clinical indicators for AD (age, sex, body mass index, years of education, and <i>APOE ε4</i> carrier status).</p><h3>Discussion</h3><p>The expression of plasma GFAP, NfL, and p-tau181 increased in the AD continuum. Importantly, plasma p-tau181 could identify individuals with AD from the general population, with superior predictive performance when combined with age or sex.</p><h3>Conclusions</h3><p>Plasma biomarkers are useful screening indicators for early AD in Chinese adults.</p></div>\",\"PeriodicalId\":7720,\"journal\":{\"name\":\"Aging Clinical and Experimental Research\",\"volume\":\"37 1\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s40520-025-03001-y.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging Clinical and Experimental Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40520-025-03001-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Clinical and Experimental Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s40520-025-03001-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
尽管基于血液的生物标志物可用于检测早期阿尔茨海默病(AD),但人群差异会影响其在疾病谱系早期诊断中的临床价值。目的探讨血浆生物标志物在中国人群中检测AD连续体不同阶段的潜力。方法我们从深圳社区招募了113名成年人(53名认知功能未受损[CU], 45名轻度认知障碍[MCI], 15名AD患者)。我们使用单分子阵列技术检测胶质纤维酸性蛋白(GFAP)、神经丝光(NfL)和磷酸化tau181 (p-tau181)的水平,并进行APOE基因分型。我们评估了血浆生物标志物与认知评分之间的关系,并使用受试者工作特征曲线来衡量早期AD诊断的表现。结果AD组血浆GFAP、NfL和p-tau181水平显著升高,MCI组血浆GFAP水平略高于CU组(GFAP p = 0.811, NfL p = 0.909, p-tau181 p = 0.696)。血浆GFAP和p-tau181水平与认知评分呈负相关。血液标志物在识别AD方面表现出比CU或MCI更高的性能。血浆p-tau181对AD的诊断价值最高。当血液标志物与AD的临床指标(年龄、性别、体重指数、受教育年数和APOE ε4携带者状态)相结合时,对认知障碍的预测更为可靠。血浆GFAP、NfL和p-tau181的表达在AD连续体中升高。重要的是,血浆p-tau181可以从一般人群中识别出AD患者,当结合年龄或性别时具有更好的预测效果。结论血浆生物标志物是中国成人早期AD的有效筛查指标。
Plasma GFAP, NfL, and p-tau181 levels as early biomarkers of dementia in Chinese adults: Shenzhen community cohort study
Background
Although blood-based biomarkers can be used to detect early Alzheimer’s disease (AD), population differences affect their clinical value in early diagnosis of the disease spectrum.
Aims
To examine the potential of plasma biomarkers to detect different stages along the AD continuum in a Chinese population.
Methods
We enrolled 113 adults from the Shenzhen community (53 cognitively unimpaired [CU], 45 with mild cognitive impairment [MCI], and 15 with AD). We used the single-molecule array technique to detect the levels of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated-tau181 (p-tau181), and performed APOE genotyping. We assessed the association between plasma biomarkers and cognitive scores, and used receiver operating characteristic curves to measure performance for early AD diagnosis.
Results
The plasma GFAP, NfL, and p-tau181 levels increased significantly in AD and were slightly higher in MCI than in CU (GFAP p = 0.811, NfL p = 0.909, p-tau181 p = 0.696). The plasma GFAP and p-tau181 levels negatively correlated with cognitive scores. Blood markers demonstrated higher performance in identifying AD than CU or MCI. Plasma p-tau181 displayed the highest diagnostic value for AD. Predictions of cognitive impairment were more robust when blood markers were combined with clinical indicators for AD (age, sex, body mass index, years of education, and APOE ε4 carrier status).
Discussion
The expression of plasma GFAP, NfL, and p-tau181 increased in the AD continuum. Importantly, plasma p-tau181 could identify individuals with AD from the general population, with superior predictive performance when combined with age or sex.
Conclusions
Plasma biomarkers are useful screening indicators for early AD in Chinese adults.
期刊介绍:
Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.