铜和NO合成酶效应器在羟基磷灰石上的吸附及牛血清白蛋白对吸附过程的影响

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-03-25 DOI:10.1007/s11172-025-4521-x

A. S. Zolotova, T. P. Trofimova, A. V. Severin, M. A. Orlova

{"title":"铜和NO合成酶效应器在羟基磷灰石上的吸附及牛血清白蛋白对吸附过程的影响","authors":"A. S. Zolotova, T. P. Trofimova, A. V. Severin, M. A. Orlova","doi":"10.1007/s11172-025-4521-x","DOIUrl":null,"url":null,"abstract":"<div>The sequential and combined sorption of bovine serum albumin (BSA) and copper ions on nanohydroxyapatite (HAP) changes the sorption capacity and sorption mechanism and affects the sorption reaction constants. Ligands, effectors of NO synthase N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide (iNOS inhibitor, L1) and N-(4-isopropylphenyl)-N-(1-imminoethyl)piperidine-1-carbothioamide hydrobromide (NOS activator, L2), are not sorbed on HAP. However, the CuL12Cl2 complex shows weak binding to HAP possibly due to a higher sorption capacity of copper ions, which can displace calcium ions.</div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 1","pages":"256 - 260"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sorption of copper and NO synthase effectors on hydroxyapatite and effect of bovine serum albumin on the sorption process\",\"authors\":\"A. S. Zolotova, T. P. Trofimova, A. V. Severin, M. A. Orlova\",\"doi\":\"10.1007/s11172-025-4521-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>The sequential and combined sorption of bovine serum albumin (BSA) and copper ions on nanohydroxyapatite (HAP) changes the sorption capacity and sorption mechanism and affects the sorption reaction constants. Ligands, effectors of NO synthase N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide (iNOS inhibitor, L1) and N-(4-isopropylphenyl)-N-(1-imminoethyl)piperidine-1-carbothioamide hydrobromide (NOS activator, L2), are not sorbed on HAP. However, the CuL12Cl2 complex shows weak binding to HAP possibly due to a higher sorption capacity of copper ions, which can displace calcium ions.</div>\",\"PeriodicalId\":756,\"journal\":{\"name\":\"Russian Chemical Bulletin\",\"volume\":\"74 1\",\"pages\":\"256 - 260\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11172-025-4521-x\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11172-025-4521-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

牛血清白蛋白（BSA）和铜离子在纳米羟基磷灰石（HAP）上的顺序吸附和联合吸附改变了吸附量和吸附机理，影响了吸附反应常数。NO合成酶N-（5,6-二氢- 4h -1,3-噻嗪-2-基）苯酰胺（iNOS抑制剂，L1）和N-（4-异丙基苯基）-N-（1-亚胺乙基）哌啶-1-碳硫酰胺氢溴化物（NOS活化剂，L2）的配体效应体在HAP上不吸附。然而，CuL12Cl2配合物与HAP的结合较弱，这可能是由于铜离子的吸附能力较高，可以取代钙离子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Sorption of copper and NO synthase effectors on hydroxyapatite and effect of bovine serum albumin on the sorption process

The sequential and combined sorption of bovine serum albumin (BSA) and copper ions on nanohydroxyapatite (HAP) changes the sorption capacity and sorption mechanism and affects the sorption reaction constants. Ligands, effectors of NO synthase N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide (iNOS inhibitor, L¹) and N-(4-isopropylphenyl)-N-(1-imminoethyl)piperidine-1-carbothioamide hydrobromide (NOS activator, L²), are not sorbed on HAP. However, the CuL¹₂Cl₂ complex shows weak binding to HAP possibly due to a higher sorption capacity of copper ions, which can displace calcium ions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.