IF 5.5 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Dongmei Hu, Qing Wu, Yujun Yang, Yan Wang, Yanhao Li, Haixiang Chen, Liang Tang, Xiang Mao, Zhenyu Wang
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引用次数: 0

摘要

金属基纳米酶具有良好的生物相容性和稳定的化学性质,可通过自由基介导的催化作用有效对抗细菌耐药性。在这项工作中,由于大多数细菌感染部位的 pH 值接近中性,针对 Fe3O4@Ag 纳米酶在中性环境中难以保持催化活性的问题,我们制备了一种新型多功能 Fe3O4@Ag@ 吲哚菁绿/三磷酸腺苷过氧化物酶纳米酶,以实现协同抗菌。ICG(吲哚菁绿)和 ATP(三磷酸腺苷)通过静电吸附作用吸附在 Fe3O4@Ag 表面形成其结构。细胞存活率保持在 90% 以上,表明其具有良好的生物相容性。通过 ATP 与纳米酶络合参与单电子转移,并与 Fe (II) 结合,ATP 促进系统中羟基自由基(-OH)的突然释放,成功地转移了 Fe3O4@Ag,使纳米酶的过氧化物酶活性扩展到中性 pH 值。利用 ICG 作为光敏剂和声敏剂,在近红外光和超声波的联合处理下,可实现光动力疗法(PDT)/光热疗法(PTT)/声动力疗法(SDT)功能,达到多功能协同抗菌效果。在中性环境下,其对革兰氏阴性菌(大肠杆菌)和革兰氏阳性菌(金黄色葡萄球菌)的杀菌效率分别为 99.9% 和 99.7%,为细菌感染提供了一种新型的多模式协同抗菌策略。制备的多功能 Fe3O4@Ag@ICG/ATP 纳米过氧化物酶具有协同抗菌活性。ICG 和 ATP 通过静电吸附作用吸附在 Fe3O4@Ag 表面,形成其结构
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bioinspired Fe3O4@Ag@ indocyanine green/adenosine triphosphate nanoenzyme in synergistic antibacterial performance

Metal-based nanoenzymes with excellent biocompatibility and stable chemical properties are an effective antimicrobial agent against bacterial resistance due to their radical-mediated catalysis. In this work, due to the pH of most bacterial infection sites being close to neutral, targeting the problem of Fe3O4@Ag difficulty in maintaining the catalytic activity of nanoenzymes in neutral environments, we prepare a novel multifunctional Fe3O4@Ag@ indocyanine green/adenosine triphosphate peroxidase nanoenzymes for synergistic antibacterial activity. ICG (Indocyanine Green) and ATP (Adenosine triphosphate) are adsorbed on the surface of Fe3O4@Ag through electrostatic adsorption to form its structure. The cell viability remained above 90%, indicating its good biocompatibility. By complexing ATP with nanoenzymes to participate in single electron transfer and binding with Fe (II), ATP promotes the sudden release of hydroxyl radical (·OH) from the system, successfully transferring Fe3O4@Ag the peroxidase activity of nanoenzymes extends to neutral pH. By utilizing ICG as a photosensitizer and a sonosensitizer, under the combined treatment of near-infrared light and ultrasound, the photodynamic therapy (PDT)/photothermal therapy (PTT)/sonodynamic therapy (SDT) functions can be achieved, achieving multifunctional synergistic antibacterial effects. In a neutral environment, its bactericidal efficiency against Gram negative (Escherichia coli) and Gram positive (Staphylococcus aureus) is 99.9% and 99.7%, respectively, providing a new multi-mode synergistic antibacterial strategy for bacterial infections.

Graphical abstract

Metal based nanoenzymes with excellent biocompatibility and stable chemical properties are an effective antimicrobial agent against bacterial resistance due to their radical mediated catalysis. The prepared multifunctional Fe3O4@Ag@ICG/ATP exhibit peroxidase nanoenzymes perform ance for synergistic antibacterial activity. ICG and ATP are adsorbed on the surface of Fe3O4@Ag through electrostatic adsorption to form its structure

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来源期刊
Nanoscale Research Letters
Nanoscale Research Letters 工程技术-材料科学:综合
CiteScore
11.30
自引率
0.00%
发文量
110
审稿时长
48 days
期刊介绍: Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.
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