再生医学用力电生物材料及装置

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2025-03-24 DOI:10.1016/j.biomaterials.2025.123288

Shuncheng Yao , Xi Cui , Chao Zhang , Wenguo Cui , Zhou Li

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引用次数: 0

摘要

越来越多的人认识到，力电转换生物材料和装置可以在没有外部电源的情况下将机械能转化为电能，从而有可能彻底改变生物医学领域电刺激的应用。基于此，本综述探讨了力电生物材料和设备在再生医学领域的应用。文章以压电生物材料、压电器件和三电器件为重点，详细介绍了它们的分类、发电机制和改善电输出性能的方法。随后，探讨了电活性生物材料和器件的不同驱动力来源。最后，介绍了力电生物材料和器件在再生医学中的生物学应用，包括组织再生、生物体功能调节和电刺激疗法。本综述旨在强调力电转换生物材料和装置产生的电刺激对生物系统中生物活性分子、离子通道和信息传递的调节作用，从而影响生物体的新陈代谢过程。未来，基于力-电转换的电刺激生理调控有望为再生医学领域带来重要的科学进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Force-electric biomaterials and devices for regenerative medicine

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Force-electric biomaterials and devices for regenerative medicine

There is a growing recognition that force-electric conversion biomaterials and devices can convert mechanical energy into electrical energy without an external power source, thus potentially revolutionizing the use of electrical stimulation in the biomedical field. Based on this, this review explores the application of force-electric biomaterials and devices in the field of regenerative medicine. The article focuses on piezoelectric biomaterials, piezoelectric devices and triboelectric devices, detailing their categorization, mechanisms of electrical generation and methods of improving electrical output performance. Subsequently, different sources of driving force for electroactive biomaterials and devices are explored. Finally, the biological applications of force-electric biomaterials and devices in regenerative medicine are presented, including tissue regeneration, functional modulation of organisms, and electrical stimulation therapy. The aim of this review is to emphasize the role of electrical stimulation generated by force-electric conversion biomaterials and devices on the regulation of bioactive molecules, ion channels and information transfer in living systems, and thus affects the metabolic processes of organisms. In the future, physiological modulation of electrical stimulation based on force-electric conversion is expected to bring important scientific advances in the field of regenerative medicine.

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来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.