通过顺序Ugi-4CR和亲核取代反应一锅合成3,4-二氢异喹啉-1(2H)- 1

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-21 DOI:10.1016/j.tet.2025.134609

Hong-Ling Pan, Han-Han Kong, Ming-Wu Ding

引用次数: 0

摘要

采用顺序Ugi-4CR和亲核取代反应制备了3,4-二氢异喹啉-1(2H)- 1的新工艺。在室温条件下，通过连续Ugi缩合和分子内亲核取代反应，可在48 - 86%的收率下合成3,4-二氢异喹啉-1(2H)- 1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

One-pot synthesis of 3,4-dihydroisoquinolin-1(2H)-ones via a sequential Ugi-4CR and nucleophilic substitution reaction

查看原文本刊更多论文

One-pot synthesis of 3,4-dihydroisoquinolin-1(2H)-ones via a sequential Ugi-4CR and nucleophilic substitution reaction

A new one-pot preparation of 3,4-dihydroisoquinolin-1(2H)-ones by a sequential Ugi-4CR and nucleophilic substitution reaction has been developed. The reactions of readily available sulfonium salts, arylglyoxals, primary amines and isocyanides produced the 3,4-dihydroisoquinolin-1(2H)-ones in 48–86 % yields via a tandem Ugi condensation and intramolecular nucleophilic substitution at room temperature in the presence of NEt₃.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.