用不同强度的体育活动替代久坐行为对抑郁症的影响：一项对等时间替代研究的荟萃分析

IF 2.3 3区医学 Q2 PSYCHIATRY

Mental Health and Physical Activity Pub Date : 2025-03-01 DOI:10.1016/j.mhpa.2025.100677

Xiaojun Liu , Zhongyan Du , Lina Wang , Jiaqi Tian , Ling Zhang , Yuanyuan Li

{"title":"用不同强度的体育活动替代久坐行为对抑郁症的影响：一项对等时间替代研究的荟萃分析","authors":"Xiaojun Liu , Zhongyan Du , Lina Wang , Jiaqi Tian , Ling Zhang , Yuanyuan Li","doi":"10.1016/j.mhpa.2025.100677","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Physical activity, sedentary behaviour and sleep are modifiable risk factors associated with depressive symptoms, but there are conflicting findings regarding their relationship. Some studies reported that increased physical activity significantly reduces depressive symptoms, while others suggested that changes in sedentary behaviour or sleep have a more significant effect on depressive symptoms. In addition, many individual studies have ignored the dependencies between these behaviours. Studies have explored the effects of replacing sedentary behaviour with physical activity on depression, but the results remain inconclusive. Therefore, we aimed to summarize the evidence from studies that have used isotemporal substitution models to explore the effects of reallocating sedentary time to different activity intensities on adults with depression.</div></div><div><h3>Methods</h3><div>From inception to July 2024, a systematic search of Chinese and English databases was conducted to look for observational studies reporting the effects of replacing sedentary behaviours with light and/or moderate to vigorous physical activity, as well as sleep on depression. Random effects meta-analyses were performed to summarize the estimated odds ratios (ORs) and regression coefficients (β) and the corresponding 95 % confidence intervals (CIs). The OR reflects the effect of the substitution effect on the risk of depression, while the β reflects the effect on the level of depression. Subgroup analyses were also performed to explore potential moderators of heterogeneity. Study quality was assessed via the Newcastle-Ottawa Scale and the Agency for Health care Research and Quality evaluation criteria.</div></div><div><h3>Results</h3><div>Seventeen studies with 136,270 participants met the inclusion criteria. Pooled analyses revealed that replacing sedentary time with LPA was not significantly associated with depression in either cross-sectional (OR = 0.93, 95 % CI: 0.77–1.13) or prospective cohort studies (OR = 0.99, 95 % CI: 0.93–1.05). Reallocating sedentary time to patients' self-reported duration of sleep was associated with a reduction in depression (OR = 0.84, 95 %CI: 0.74–0.96). An accelerometer was used to measure physical activity, and replacing sedentary time with MVPA was cross-sectionally associated with depression (OR = 0.79, 95 % CI: 0.69–0.91), but no longitudinal association was found.</div></div><div><h3>Conclusion</h3><div>Replacing sedentary behaviours with moderate to vigorous physical activity and sleep may reduce the odds ratio of depression, but more research is needed to demonstrate the role of light-intensity physical activity on depression. Exercise guidelines and effective strategies to prevent depression must be developed to integrate the interplay of activity behaviours and provide targeted recommendations for time reallocation.</div></div>","PeriodicalId":51589,"journal":{"name":"Mental Health and Physical Activity","volume":"28 ","pages":"Article 100677"},"PeriodicalIF":2.3000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of replacing sedentary behaviour with different intensities of physical activity on depression: A meta-analysis of isotemporal substitution studies\",\"authors\":\"Xiaojun Liu , Zhongyan Du , Lina Wang , Jiaqi Tian , Ling Zhang , Yuanyuan Li\",\"doi\":\"10.1016/j.mhpa.2025.100677\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Physical activity, sedentary behaviour and sleep are modifiable risk factors associated with depressive symptoms, but there are conflicting findings regarding their relationship. Some studies reported that increased physical activity significantly reduces depressive symptoms, while others suggested that changes in sedentary behaviour or sleep have a more significant effect on depressive symptoms. In addition, many individual studies have ignored the dependencies between these behaviours. Studies have explored the effects of replacing sedentary behaviour with physical activity on depression, but the results remain inconclusive. Therefore, we aimed to summarize the evidence from studies that have used isotemporal substitution models to explore the effects of reallocating sedentary time to different activity intensities on adults with depression.</div></div><div><h3>Methods</h3><div>From inception to July 2024, a systematic search of Chinese and English databases was conducted to look for observational studies reporting the effects of replacing sedentary behaviours with light and/or moderate to vigorous physical activity, as well as sleep on depression. Random effects meta-analyses were performed to summarize the estimated odds ratios (ORs) and regression coefficients (β) and the corresponding 95 % confidence intervals (CIs). The OR reflects the effect of the substitution effect on the risk of depression, while the β reflects the effect on the level of depression. Subgroup analyses were also performed to explore potential moderators of heterogeneity. Study quality was assessed via the Newcastle-Ottawa Scale and the Agency for Health care Research and Quality evaluation criteria.</div></div><div><h3>Results</h3><div>Seventeen studies with 136,270 participants met the inclusion criteria. Pooled analyses revealed that replacing sedentary time with LPA was not significantly associated with depression in either cross-sectional (OR = 0.93, 95 % CI: 0.77–1.13) or prospective cohort studies (OR = 0.99, 95 % CI: 0.93–1.05). Reallocating sedentary time to patients' self-reported duration of sleep was associated with a reduction in depression (OR = 0.84, 95 %CI: 0.74–0.96). An accelerometer was used to measure physical activity, and replacing sedentary time with MVPA was cross-sectionally associated with depression (OR = 0.79, 95 % CI: 0.69–0.91), but no longitudinal association was found.</div></div><div><h3>Conclusion</h3><div>Replacing sedentary behaviours with moderate to vigorous physical activity and sleep may reduce the odds ratio of depression, but more research is needed to demonstrate the role of light-intensity physical activity on depression. Exercise guidelines and effective strategies to prevent depression must be developed to integrate the interplay of activity behaviours and provide targeted recommendations for time reallocation.</div></div>\",\"PeriodicalId\":51589,\"journal\":{\"name\":\"Mental Health and Physical Activity\",\"volume\":\"28 \",\"pages\":\"Article 100677\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mental Health and Physical Activity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1755296625000080\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mental Health and Physical Activity","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1755296625000080","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

摘要

体育活动、久坐行为和睡眠是与抑郁症状相关的可改变的危险因素，但关于它们之间的关系，有相互矛盾的发现。一些研究报告称，增加体育活动可以显著减轻抑郁症状，而另一些研究则表明，久坐行为或睡眠的改变对抑郁症状有更显著的影响。此外，许多个体研究忽略了这些行为之间的依赖关系。研究已经探索了用体育活动取代久坐行为对抑郁症的影响，但结果仍然没有定论。因此，我们旨在总结使用等时间替代模型的研究证据，以探索将久坐时间重新分配到不同的活动强度对成年人抑郁症的影响。方法：从开始到2024年7月，对中英文数据库进行了系统搜索，寻找观察性研究，报告用轻度和/或中度到剧烈的体育活动以及睡眠取代久坐行为对抑郁症的影响。随机效应荟萃分析总结了估计的比值比（ORs）和回归系数（β）以及相应的95%置信区间（ci）。OR反映替代效应对抑郁风险的影响，β反映替代效应对抑郁水平的影响。亚组分析也用于探索异质性的潜在调节因子。研究质量通过纽卡斯尔-渥太华量表和卫生保健研究和质量评估标准机构进行评估。结果17项研究136270名受试者符合纳入标准。合并分析显示，在横断面研究（OR = 0.93, 95% CI: 0.77-1.13）或前瞻性队列研究（OR = 0.99, 95% CI: 0.93 - 1.05）中，用LPA代替久坐时间与抑郁症没有显著相关性。根据患者自我报告的睡眠时间重新分配久坐时间与抑郁症的减少相关（OR = 0.84, 95% CI: 0.74-0.96）。使用加速计测量身体活动，用MVPA代替久坐时间与抑郁呈横断面相关性（OR = 0.79, 95% CI: 0.69-0.91），但未发现纵向相关性。结论以中高强度运动和睡眠取代久坐行为可降低抑郁症的比值比，但需要更多的研究来证明轻强度运动对抑郁症的作用。必须制定运动指南和预防抑郁症的有效策略，以整合活动行为的相互作用，并为时间重新分配提供有针对性的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The effect of replacing sedentary behaviour with different intensities of physical activity on depression: A meta-analysis of isotemporal substitution studies

Objective

Physical activity, sedentary behaviour and sleep are modifiable risk factors associated with depressive symptoms, but there are conflicting findings regarding their relationship. Some studies reported that increased physical activity significantly reduces depressive symptoms, while others suggested that changes in sedentary behaviour or sleep have a more significant effect on depressive symptoms. In addition, many individual studies have ignored the dependencies between these behaviours. Studies have explored the effects of replacing sedentary behaviour with physical activity on depression, but the results remain inconclusive. Therefore, we aimed to summarize the evidence from studies that have used isotemporal substitution models to explore the effects of reallocating sedentary time to different activity intensities on adults with depression.

Methods

From inception to July 2024, a systematic search of Chinese and English databases was conducted to look for observational studies reporting the effects of replacing sedentary behaviours with light and/or moderate to vigorous physical activity, as well as sleep on depression. Random effects meta-analyses were performed to summarize the estimated odds ratios (ORs) and regression coefficients (β) and the corresponding 95 % confidence intervals (CIs). The OR reflects the effect of the substitution effect on the risk of depression, while the β reflects the effect on the level of depression. Subgroup analyses were also performed to explore potential moderators of heterogeneity. Study quality was assessed via the Newcastle-Ottawa Scale and the Agency for Health care Research and Quality evaluation criteria.

Results

Seventeen studies with 136,270 participants met the inclusion criteria. Pooled analyses revealed that replacing sedentary time with LPA was not significantly associated with depression in either cross-sectional (OR = 0.93, 95 % CI: 0.77–1.13) or prospective cohort studies (OR = 0.99, 95 % CI: 0.93–1.05). Reallocating sedentary time to patients' self-reported duration of sleep was associated with a reduction in depression (OR = 0.84, 95 %CI: 0.74–0.96). An accelerometer was used to measure physical activity, and replacing sedentary time with MVPA was cross-sectionally associated with depression (OR = 0.79, 95 % CI: 0.69–0.91), but no longitudinal association was found.

Conclusion

Replacing sedentary behaviours with moderate to vigorous physical activity and sleep may reduce the odds ratio of depression, but more research is needed to demonstrate the role of light-intensity physical activity on depression. Exercise guidelines and effective strategies to prevent depression must be developed to integrate the interplay of activity behaviours and provide targeted recommendations for time reallocation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Mental Health and Physical Activity PSYCHIATRY-

CiteScore

6.70

自引率

6.40%

发文量

审稿时长

32 days

期刊介绍： The aims of Mental Health and Physical Activity will be: (1) to foster the inter-disciplinary development and understanding of the mental health and physical activity field; (2) to develop research designs and methods to advance our understanding; (3) to promote the publication of high quality research on the effects of physical activity (interventions and a single session) on a wide range of dimensions of mental health and psychological well-being (eg, depression, anxiety and stress responses, mood, cognitive functioning and neurological disorders, such as dementia, self-esteem and related constructs, psychological aspects of quality of life among people with physical and mental illness, sleep, addictive disorders, eating disorders), from both efficacy and effectiveness trials;