重新审视CBL在肝纤维化中的作用：揭示CBLB抑制剂NX-1607的抗纤维化潜力

IF 26.8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepatology Pub Date : 2025-03-25 DOI:10.1016/j.jhep.2025.03.023

Kaikai Lu, Yitong Xu, Lei He, Yinqi Zhao, Xunde Xian

{"title":"重新审视CBL在肝纤维化中的作用：揭示CBLB抑制剂NX-1607的抗纤维化潜力","authors":"Kaikai Lu, Yitong Xu, Lei He, Yinqi Zhao, Xunde Xian","doi":"10.1016/j.jhep.2025.03.023","DOIUrl":null,"url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>K.L. and X.X. designed the research study; K.L., Y.X., L.H. and Y.Z. conducted experiments; K.L. analyzed data; K.L., L.H., and X.X. wrote the manuscript.</section></section><section><section><h2>Data availability statement</h2>The data that support the findings of this study are available from the corresponding authors upon request.</section></section><section><section><h2>Financial support</h2>This work was supported by the National Natural Science Foundation of China (NSFC) 82270479,82070460 and HY2021-1 to Xunde Xian; the Beijing Natural Science Foundation 7242084 to Xunde Xian; the Fundamental Research Funds for the Central Universities to Xunde Xian; Peking University Medicine plus X Pilot Program-Platform Construction Project 2024YXXLHPT010 to Xunde Xian.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no competing interests. Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"47 1","pages":""},"PeriodicalIF":26.8000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Revisiting the Role of CBL in Liver Fibrosis: Unveiling the Antifibrotic Potential of CBLB inhibitor NX-1607\",\"authors\":\"Kaikai Lu, Yitong Xu, Lei He, Yinqi Zhao, Xunde Xian\",\"doi\":\"10.1016/j.jhep.2025.03.023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>K.L. and X.X. designed the research study; K.L., Y.X., L.H. and Y.Z. conducted experiments; K.L. analyzed data; K.L., L.H., and X.X. wrote the manuscript.</section></section><section><section><h2>Data availability statement</h2>The data that support the findings of this study are available from the corresponding authors upon request.</section></section><section><section><h2>Financial support</h2>This work was supported by the National Natural Science Foundation of China (NSFC) 82270479,82070460 and HY2021-1 to Xunde Xian; the Beijing Natural Science Foundation 7242084 to Xunde Xian; the Fundamental Research Funds for the Central Universities to Xunde Xian; Peking University Medicine plus X Pilot Program-Platform Construction Project 2024YXXLHPT010 to Xunde Xian.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no competing interests. Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>\",\"PeriodicalId\":15888,\"journal\":{\"name\":\"Journal of Hepatology\",\"volume\":\"47 1\",\"pages\":\"\"},\"PeriodicalIF\":26.8000,\"publicationDate\":\"2025-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jhep.2025.03.023\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhep.2025.03.023","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

章节片段作者的贡献和X.X.设计了研究研究；K.L, yx， L.H.和yz进行实验；K.L.分析数据；k.l., l.h.和X.X.写了手稿。数据可用性声明支持本研究结果的数据可应要求从通讯作者处获得。国家自然科学基金（NSFC） 82270479、82070460和HY2021-1资助至冼勋德；北京市自然科学基金7242084资助冼勋德；中央高校基本科研业务费资助项目；北京大学医学+ X试点项目-西安训德2024YXXLHPT010平台建设项目。竞争利益声明作者声明没有竞争利益。详情请参阅随附的ICMJE披露表格。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Revisiting the Role of CBL in Liver Fibrosis: Unveiling the Antifibrotic Potential of CBLB inhibitor NX-1607

Section snippets

Authors' contributions

K.L. and X.X. designed the research study; K.L., Y.X., L.H. and Y.Z. conducted experiments; K.L. analyzed data; K.L., L.H., and X.X. wrote the manuscript.

Data availability statement

The data that support the findings of this study are available from the corresponding authors upon request.

Financial support

This work was supported by the National Natural Science Foundation of China (NSFC) 82270479,82070460 and HY2021-1 to Xunde Xian; the Beijing Natural Science Foundation 7242084 to Xunde Xian; the Fundamental Research Funds for the Central Universities to Xunde Xian; Peking University Medicine plus X Pilot Program-Platform Construction Project 2024YXXLHPT010 to Xunde Xian.

Declaration of Competing Interest

The authors declare no competing interests. Please refer to the accompanying ICMJE disclosure forms for further details.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Hepatology 医学-胃肠肝病学

CiteScore

46.10

自引率

4.30%

发文量

2325

审稿时长

30 days

期刊介绍： The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.