亚细胞细胞器靶向肿瘤光疗

IF 20.3 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews Pub Date : 2025-03-25 DOI:10.1016/j.ccr.2025.216635

Man Lu , Mingjing Huang , Jing Chen , Xingyan Xu , Shudi Liu , Wenjun Wang , Weili Si , Xin Huang , Xiaochen Dong

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引用次数: 0

摘要

光疗具有微创、低毒、高效、可控等优点，已成为一种前景广阔的癌症治疗方法。亚细胞器靶向光疗在光疗中发挥着至关重要的作用，它能确保精确的靶向给药、减少药物剂量并提高治疗效率。本综述主要介绍细胞器亚细胞靶向肿瘤光疗的最新进展。首先，它介绍了各种亚细胞器的结构和功能，包括线粒体、溶酶体、内质网、细胞核、高尔基体和细胞膜。然后，以有机小分子、金属复合物和其他纳米材料为基础，介绍了具有亚细胞器靶向特性的肿瘤光敏剂/光热剂的光治疗进展。具体而言，讨论了根据亚细胞器的特殊特征开发的这些材料以及根除恶性肿瘤的相关机制。最后，总结了亚细胞器靶向光疗癌症所面临的挑战。

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Subcellular organelle targeted tumor phototherapy

Phototherapy has emerged as a promising approach for cancer treatment, attributed to its advantages of being minimally invasive, low toxicity, high efficiency, and controllability. Subcellular organelle-targeted phototherapy plays a crucial role in phototherapy by ensuring precise targeted drug delivery, reducing medication dosage, and improving therapeutic efficiency. This review focuses on recent advancements in subcellular organelle-targeted tumor phototherapy. Firstly, it introduces the structure and function of various subcellular organelles, including mitochondria, lysosomes, endoplasmic reticulum, nucleus, Golgi apparatus, and cell membrane. Then, the advances of photosensitizers/photothermal agents with subcellular organelle-targeting properties for tumor phototherapeutics are presented based on organic small molecules, metal complexes, and other nanomaterials. Specifically, these materials developed on the particular features of subcellular organelles and related mechanisms to eradicate malignancies are discussed. Lastly, the challenges of subcellular organelle-targeted phototherapy for cancer are summarized.

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.