Outside Back Cover: DNA Framework-Ensembled Aptamers Enhance Fluid Stability in Circulating Tumor Cells Capture for Tumor Treatment Evaluation

Framework nucleic acids (FNAs), as precisely engineered structural nucleic acids, enable precise regulation of molecular recognition between receptors and ligands. In their Research Article (e202425252), Xiaolei Zuo and co-workers developed a tetrahedral DNA framework-engineered multivalent aptamer system (TEAn) for the highly efficient capture of circulating tumor cells (CTCs) and accurate monitoring of clinical treatment progression.