Zehua Wang, Ye Zhang, Ning Ma, Huiting Qiao, Meiyun Xia, Deyu Li
{"title":"基于光电神经信息的认知损伤评估研究。","authors":"Zehua Wang, Ye Zhang, Ning Ma, Huiting Qiao, Meiyun Xia, Deyu Li","doi":"10.1177/25424823251325537","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Whether there is a cognitive load-dependent brain activation pattern in the pre-Alzheimer's disease phase is unknown. Multimodal system provides a powerful technical tool.</p><p><strong>Objective: </strong>We evaluated brain activity patterns under different cognitive loads in patients with mild cognitive impairment.</p><p><strong>Methods: </strong>Functional near-infrared spectroscopy signals and electroencephalography signals were acquired from the mild cognitive impairment group (MCI, n = 20) and the healthy control group (HC, n = 24) under four cognitive loads. We analyzed the respective brain activity features and performed correlation analyses.</p><p><strong>Results: </strong>(1) During the encoding phase, both the left occipital (<i>p</i> <sub>cond </sub>= 0.05, <i>p</i> <sub>group </sub>< 0.01) and left temporal (<i>p</i> <sub>cond </sub>= 0.02, <i>p</i> <sub>group </sub>= 0.03) skewness condition effects and between-group effects were significant. (2) As the cognitive load increased, the clustering coefficients and local efficiencies were significantly lower for the HC group. (3) The left occipital and left temporal activation skewness in the MCI group were significantly correlated with left occipital electrical features, whereas the left occipital activation intensity and skewness were significantly correlated with left occipital electrical features in HC group.</p><p><strong>Conclusions: </strong>The pattern of brain activity in MCI depends on cognitive load. Left occipital and left temporal may be important brain regions for evaluating MCI and need to be focused on in the future.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251325537"},"PeriodicalIF":2.8000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930469/pdf/","citationCount":"0","resultStr":"{\"title\":\"Study on cognitive impairment evaluation based on photoelectric neural information.\",\"authors\":\"Zehua Wang, Ye Zhang, Ning Ma, Huiting Qiao, Meiyun Xia, Deyu Li\",\"doi\":\"10.1177/25424823251325537\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Whether there is a cognitive load-dependent brain activation pattern in the pre-Alzheimer's disease phase is unknown. Multimodal system provides a powerful technical tool.</p><p><strong>Objective: </strong>We evaluated brain activity patterns under different cognitive loads in patients with mild cognitive impairment.</p><p><strong>Methods: </strong>Functional near-infrared spectroscopy signals and electroencephalography signals were acquired from the mild cognitive impairment group (MCI, n = 20) and the healthy control group (HC, n = 24) under four cognitive loads. We analyzed the respective brain activity features and performed correlation analyses.</p><p><strong>Results: </strong>(1) During the encoding phase, both the left occipital (<i>p</i> <sub>cond </sub>= 0.05, <i>p</i> <sub>group </sub>< 0.01) and left temporal (<i>p</i> <sub>cond </sub>= 0.02, <i>p</i> <sub>group </sub>= 0.03) skewness condition effects and between-group effects were significant. (2) As the cognitive load increased, the clustering coefficients and local efficiencies were significantly lower for the HC group. (3) The left occipital and left temporal activation skewness in the MCI group were significantly correlated with left occipital electrical features, whereas the left occipital activation intensity and skewness were significantly correlated with left occipital electrical features in HC group.</p><p><strong>Conclusions: </strong>The pattern of brain activity in MCI depends on cognitive load. Left occipital and left temporal may be important brain regions for evaluating MCI and need to be focused on in the future.</p>\",\"PeriodicalId\":73594,\"journal\":{\"name\":\"Journal of Alzheimer's disease reports\",\"volume\":\"9 \",\"pages\":\"25424823251325537\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930469/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's disease reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/25424823251325537\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's disease reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25424823251325537","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景:在阿尔茨海默病前期是否存在认知负荷依赖的脑激活模式尚不清楚。多式联运系统提供了强大的技术工具。目的:研究轻度认知障碍患者在不同认知负荷下的脑活动模式。方法:采集轻度认知障碍组(MCI, n = 20)和健康对照组(HC, n = 24)在4种认知负荷下的功能近红外光谱信号和脑电图信号。我们分析了各自的大脑活动特征并进行了相关性分析。结果:(1)编码阶段左枕部偏度条件效应(p cond = 0.05, p组p cond = 0.02, p组= 0.03)和组间效应均显著。(2)随着认知负荷的增加,HC组的聚类系数和局部效率显著降低。(3) MCI组左枕部和左颞部激活偏度与左枕部电特征显著相关,HC组左枕部激活强度和偏度与左枕部电特征显著相关。结论:轻度认知损伤的脑活动模式与认知负荷有关。左枕叶和左颞叶可能是评估轻度认知损伤的重要脑区,未来需要重点研究。
Study on cognitive impairment evaluation based on photoelectric neural information.
Background: Whether there is a cognitive load-dependent brain activation pattern in the pre-Alzheimer's disease phase is unknown. Multimodal system provides a powerful technical tool.
Objective: We evaluated brain activity patterns under different cognitive loads in patients with mild cognitive impairment.
Methods: Functional near-infrared spectroscopy signals and electroencephalography signals were acquired from the mild cognitive impairment group (MCI, n = 20) and the healthy control group (HC, n = 24) under four cognitive loads. We analyzed the respective brain activity features and performed correlation analyses.
Results: (1) During the encoding phase, both the left occipital (pcond = 0.05, pgroup < 0.01) and left temporal (pcond = 0.02, pgroup = 0.03) skewness condition effects and between-group effects were significant. (2) As the cognitive load increased, the clustering coefficients and local efficiencies were significantly lower for the HC group. (3) The left occipital and left temporal activation skewness in the MCI group were significantly correlated with left occipital electrical features, whereas the left occipital activation intensity and skewness were significantly correlated with left occipital electrical features in HC group.
Conclusions: The pattern of brain activity in MCI depends on cognitive load. Left occipital and left temporal may be important brain regions for evaluating MCI and need to be focused on in the future.