神经退行性疾病和其他脑部疾病的人源化啮齿动物模型。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2025-03-20 DOI:10.1016/j.neubiorev.2025.106112

Xinru Zhang , Jianxiang Wang , Jiewen Zhang , Chao Jiang , Xuezhong Liu , Shuaijiang Wang , Zhenhua Zhang , Yousef Rastegar-Kashkooli , Fatemeh Dialameh , Qinfeng Peng , Jin Tao , Ruoqi Ding , Junyang Wang , Nannan Cheng , Menglu Wang , Fushun Wang , Nan Li , Na Xing , Xuemei Chen , Xiaochong Fan , Jian Wang

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引用次数: 0

摘要

中枢神经系统疾病严重影响人体健康。然而，在啮齿类动物中复制这些疾病的发病、进展和病理是具有挑战性的。为了解决这个问题，研究人员开发了人性化的动物模型。这些模型将人类基因或细胞引入啮齿类动物体内。因此，啮齿动物更适合在体内研究人类中枢神经系统疾病及其治疗方法。本文综述了人源化啮齿动物模型在研究各种中枢神经系统疾病，特别是阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩侧索硬化症、神经胶质细胞相关中枢神经系统疾病、n -甲基- d -天冬氨酸受体脑炎等方面的制备方案、病理和行为特点、益处、意义和局限性。人源化啮齿类动物模型扩大了在体内探索人类神经退行性疾病、其他脑部疾病及其治疗的机会。我们可以通过开发、调查和利用这些模型来加强对中枢神经系统疾病的转化研究。

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Humanized rodent models of neurodegenerative diseases and other brain disorders

Central Nervous System (CNS) diseases significantly affect human health. However, replicating the onset, progression, and pathology of these diseases in rodents is challenging. To address this issue, researchers have developed humanized animal models. These models introduce human genes or cells into rodents. As a result, rodents become more suitable for studying human CNS diseases and their therapies in vivo. This review explores the preparation protocols, pathological and behavioral characteristics, benefits, significance, and limitations of humanized rodent models in researching various CNS diseases, particularly Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, glial cells-related CNS diseases, N-methyl-D-aspartic acid receptor encephalitis, and others. Humanized rodent models have expanded the opportunities for in vivo exploration of human neurodegenerative diseases, other brain disorders, and their treatments. We can enhance translational research on CNS disorders by developing, investigating, and utilizing these models.

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.