Federico Belladelli, Riccardo Ramadani, Marco Malvestiti, Edoardo Pozzi, Christian Corsini, Massimiliano Raffo, Fausto Negri, Alessandro Bertini, Simone Cilio, Luca Boeri, Massimo Alfano, Giovanni Lavorgna, Alessia d'Arma, Francesco Montorsi, Andrea Salonia
{"title":"揭示家族关系：不育男性精子DNA断裂指数升高与家族性癌症易感性。","authors":"Federico Belladelli, Riccardo Ramadani, Marco Malvestiti, Edoardo Pozzi, Christian Corsini, Massimiliano Raffo, Fausto Negri, Alessandro Bertini, Simone Cilio, Luca Boeri, Massimo Alfano, Giovanni Lavorgna, Alessia d'Arma, Francesco Montorsi, Andrea Salonia","doi":"10.1016/j.xfss.2025.03.002","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study the potential association between pure male factor infertility (MFI) and the likelihood of a positive family history of cancer because limited information exists on the oncologic risk among relatives of men experiencing infertility.</p><p><strong>Design: </strong>This cross-sectional, retrospective analysis considered the latest 1,168 men seeking medical help for primary couple's infertility at a single center. Infertility was defined according to the World Health Organization criteria.</p><p><strong>Subjects: </strong>A total of 1,168 men seeking medical help for primary couple's infertility at a single center.</p><p><strong>Intervention(s): </strong>Patients underwent thorough assessments, including medical history, measured body mass index, laboratory investigations including semen analyses and sperm DNA fragmentation (SDF) index testing.</p><p><strong>Main outcome measure(s): </strong>Abnormal SDF was defined as >30%. Descriptive statistics and logistic regression analyses tested the association between semen parameters, SDF, and positive cancer family history.</p><p><strong>Result(s): </strong>Of 1,168, 168 (14.4%) patients reported a positive cancer familial history. Patients with positive cancer family history were older (median interquartile range [IQR]: 37.00 [33.00-41.00] vs. 38.00 [34.00-41.00] years) and more frequently smokers (271 [27.1] vs. 64 [38.1]). Positive family history for malignancies was observed in 79 (40.9%), 66 (34.2%), 36 (18.7%), and 6 (3.1%) patients with a 1st, 2nd, 3rd, and 4th degree of kinship, respectively. At multivariable logistic regression analysis, SDF was positively associated with an increased risk of positive cancer family history in any (HR, 1.12; 95% CI, 1.04-2.1) and in 1st-degree relatives (HR, 1.01; 95% CI, 1.00-1.03). Similarly, abnormal SDF was associated with an increased risk of positive cancer family history in any relative (HR, 1.78; 95% CI, 1.12-2.87) and in 1st-degree relatives (HR, 1.92; 95% CI, 1.01-3.84).</p><p><strong>Conclusion: </strong>Almost 14% of patients with MFI reported a familial history of cancer. Greater SDF levels emerged to be associated with a higher likelihood of a positive family history of cancer.</p>","PeriodicalId":73012,"journal":{"name":"F&S science","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unraveling familial ties: elevated sperm DNA fragmentation index in men with infertility and familial cancer susceptibility.\",\"authors\":\"Federico Belladelli, Riccardo Ramadani, Marco Malvestiti, Edoardo Pozzi, Christian Corsini, Massimiliano Raffo, Fausto Negri, Alessandro Bertini, Simone Cilio, Luca Boeri, Massimo Alfano, Giovanni Lavorgna, Alessia d'Arma, Francesco Montorsi, Andrea Salonia\",\"doi\":\"10.1016/j.xfss.2025.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study the potential association between pure male factor infertility (MFI) and the likelihood of a positive family history of cancer because limited information exists on the oncologic risk among relatives of men experiencing infertility.</p><p><strong>Design: </strong>This cross-sectional, retrospective analysis considered the latest 1,168 men seeking medical help for primary couple's infertility at a single center. Infertility was defined according to the World Health Organization criteria.</p><p><strong>Subjects: </strong>A total of 1,168 men seeking medical help for primary couple's infertility at a single center.</p><p><strong>Intervention(s): </strong>Patients underwent thorough assessments, including medical history, measured body mass index, laboratory investigations including semen analyses and sperm DNA fragmentation (SDF) index testing.</p><p><strong>Main outcome measure(s): </strong>Abnormal SDF was defined as >30%. Descriptive statistics and logistic regression analyses tested the association between semen parameters, SDF, and positive cancer family history.</p><p><strong>Result(s): </strong>Of 1,168, 168 (14.4%) patients reported a positive cancer familial history. Patients with positive cancer family history were older (median interquartile range [IQR]: 37.00 [33.00-41.00] vs. 38.00 [34.00-41.00] years) and more frequently smokers (271 [27.1] vs. 64 [38.1]). Positive family history for malignancies was observed in 79 (40.9%), 66 (34.2%), 36 (18.7%), and 6 (3.1%) patients with a 1st, 2nd, 3rd, and 4th degree of kinship, respectively. At multivariable logistic regression analysis, SDF was positively associated with an increased risk of positive cancer family history in any (HR, 1.12; 95% CI, 1.04-2.1) and in 1st-degree relatives (HR, 1.01; 95% CI, 1.00-1.03). Similarly, abnormal SDF was associated with an increased risk of positive cancer family history in any relative (HR, 1.78; 95% CI, 1.12-2.87) and in 1st-degree relatives (HR, 1.92; 95% CI, 1.01-3.84).</p><p><strong>Conclusion: </strong>Almost 14% of patients with MFI reported a familial history of cancer. Greater SDF levels emerged to be associated with a higher likelihood of a positive family history of cancer.</p>\",\"PeriodicalId\":73012,\"journal\":{\"name\":\"F&S science\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"F&S science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.xfss.2025.03.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"F&S science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.xfss.2025.03.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Unraveling familial ties: elevated sperm DNA fragmentation index in men with infertility and familial cancer susceptibility.
Objective: To study the potential association between pure male factor infertility (MFI) and the likelihood of a positive family history of cancer because limited information exists on the oncologic risk among relatives of men experiencing infertility.
Design: This cross-sectional, retrospective analysis considered the latest 1,168 men seeking medical help for primary couple's infertility at a single center. Infertility was defined according to the World Health Organization criteria.
Subjects: A total of 1,168 men seeking medical help for primary couple's infertility at a single center.
Intervention(s): Patients underwent thorough assessments, including medical history, measured body mass index, laboratory investigations including semen analyses and sperm DNA fragmentation (SDF) index testing.
Main outcome measure(s): Abnormal SDF was defined as >30%. Descriptive statistics and logistic regression analyses tested the association between semen parameters, SDF, and positive cancer family history.
Result(s): Of 1,168, 168 (14.4%) patients reported a positive cancer familial history. Patients with positive cancer family history were older (median interquartile range [IQR]: 37.00 [33.00-41.00] vs. 38.00 [34.00-41.00] years) and more frequently smokers (271 [27.1] vs. 64 [38.1]). Positive family history for malignancies was observed in 79 (40.9%), 66 (34.2%), 36 (18.7%), and 6 (3.1%) patients with a 1st, 2nd, 3rd, and 4th degree of kinship, respectively. At multivariable logistic regression analysis, SDF was positively associated with an increased risk of positive cancer family history in any (HR, 1.12; 95% CI, 1.04-2.1) and in 1st-degree relatives (HR, 1.01; 95% CI, 1.00-1.03). Similarly, abnormal SDF was associated with an increased risk of positive cancer family history in any relative (HR, 1.78; 95% CI, 1.12-2.87) and in 1st-degree relatives (HR, 1.92; 95% CI, 1.01-3.84).
Conclusion: Almost 14% of patients with MFI reported a familial history of cancer. Greater SDF levels emerged to be associated with a higher likelihood of a positive family history of cancer.
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