除焦亡外，气皮素D的多功能性。

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-03-21 DOI:10.1016/j.tcb.2025.02.011

Tianming Zhao, Zhexu Chi, Di Wang

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引用次数: 0

摘要

Gasdermin D （GSDMD）引起了广泛关注，主要是因为其p30 n端片段（NT-p30）在细胞焦亡（一种促炎症的细胞死亡形式）过程中产生的孔形成作用。然而，新出现的证据表明，GSDMD- nt孔的形成是可逆的，GSDMD的激活并不一定导致焦亡。相反，这一过程可能参与其他形式的细胞死亡，或参与活细胞的各种状态变化，包括(i)炎症调节，（ii）内溶酶体途径重新连接，（iii）颗粒胞吐，（iv） ii型免疫，(v)食物耐受性维持，以及（vi）暂时性渗透性改变。本文综述了GSDMD参与细胞死亡和体内平衡维持的最新见解，旨在强调GSDMD的多效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Versatility of gasdermin D beyond pyroptosis.

Gasdermin D (GSDMD) has garnered significant attention primarily for the pore-forming role of its p30 N-terminal fragment (NT-p30) generated during pyroptosis, a proinflammatory form of cell death. However, emerging evidence suggests that the formation of GSDMD-NT pores is reversible, and the activation of GSDMD does not necessarily lead to pyroptosis. Instead, this process may take part either in other forms of cell death, or in various state changes of living cells, including (i) inflammation regulation, (ii) endolysosomal pathway rewiring, (iii) granule exocytosis, (iv) type II immunity, (v) food tolerance maintenance, and (vi) temporary permeability alteration. This review explores the latest insights into the involvement of GSDMD in cell death and homeostasis maintenance, aiming to underscore the pleiotropic nature of GSDMD.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.