肺结核中的氧化斗争：走铁的钢丝。

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-04-01 Epub Date: 2025-03-22 DOI:10.1016/j.it.2025.02.009

Mariana Araújo-Pereira, Bruno B Andrade

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引用次数: 0

摘要

由结核分枝杆菌（Mtb）引起的结核病（TB）仍然是全世界死亡的主要原因之一。结核病的发病机制是由病原体和宿主免疫反应之间复杂的相互作用形成的，特别是通过氧化应激和铁下垂等机制；一种由铁依赖性脂质过氧化作用驱动的受调节的坏死细胞死亡形式。这篇综述强调了最近关于结核分枝杆菌如何调节氧化应激途径从而引发宿主细胞铁死亡的见解。了解氧化应激反应与细胞和组织坏死之间的相互作用，通过控制细菌生长和防止宿主组织损伤，为结核病的治疗干预开辟了新的途径。

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Oxidative battles in tuberculosis: walking the ferroptotic tightrope.

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the leading causes of death worldwide. TB pathogenesis is shaped by a complex interaction between the pathogen and host immune responses, particularly through mechanisms such as oxidative stress and ferroptosis; a form of regulated necrotic cell death driven by iron-dependent lipid peroxidation. This Review highlights recent insights into how Mtb modulates oxidative stress pathways and thus triggers ferroptosis in host cells. Understanding the interplay between oxidative stress responses and cellular and tissue necrosis opens new avenues for therapeutic interventions of TB by controlling bacterial growth and preventing host tissue damage.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.