小动脉闭塞或腔隙性脑卒中后不良预后的危险因素分析:一项回顾性队列研究。

IF 2.7 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Risk Management and Healthcare Policy Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI:10.2147/RMHP.S482736
Yan Shi, Yongtao Liu, Jingjing Sun, Bing Zhao, Qingfan Xie
{"title":"小动脉闭塞或腔隙性脑卒中后不良预后的危险因素分析:一项回顾性队列研究。","authors":"Yan Shi, Yongtao Liu, Jingjing Sun, Bing Zhao, Qingfan Xie","doi":"10.2147/RMHP.S482736","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the risk factors and predictive value for poor prognosis following small artery occlusion stroke (SAO) or lacunar stroke.</p><p><strong>Methods: </strong>A retrospective cohort of 100 SAO patients who received their first intravenous thrombolysis (IVT) treatment with alteplase between March 2019 and March 2021 was collected. Based on the modified Rankin Scale (mRS) score of <3 at 90 days post-admission, patients were divided into a good prognosis group (61 cases) and a poor prognosis group (39 cases) for comparative analysis.</p><p><strong>Results: </strong>In our retrospective cohort study of 100 SAO patients treated with IVT from March 2019 to March 2021, we found no significant differences in gender, age or BMI between the 61 patients with good prognosis and the 39 with poor prognosis, although smoking habits varied. Statistically differences were observed between the two groups in terms of time from onset to hospital admission for thrombolysis (48.59±20.14 vs 40.03±23.73 min, <i>t</i>=2.202, <i>P</i>=0.030), triglycerides (1.56±0.92 vs 1.20±0.68 mmol/L, <i>t</i>=2.069, <i>P</i>=0.041), and smoking prevalence (42.62% vs 20.51%, <i>χ<sup>2</sup></i> =5.183, <i>P</i>=0.023). Regression analysis indicated that shorter time from onset to hospital admission for thrombolysis (<i>OR</i>=0.978, 95% CI: 0.957-0.993) was a protective factor against poor prognosis post-thrombolysis in SAO patients, while a history of smoking (<i>OR</i>=2.881, 95% CI: 1.115-7.444) was a risk factor for poor prognosis post-thrombolysis. The area under the curve (AUC) for predicting poor prognosis post-thrombolysis in SAO patients based on time from onset to hospital admission was 0.662 (95% CI: 0.552-0.771), with a cutoff value of 36.5 min; the AUC for predicting poor prognosis based on smoking history was 0.614 (95% CI: 0.502-0.726).</p><p><strong>Conclusion: </strong>An extended duration from onset to hospital admission for thrombolysis and smoking are identified as significant risk factors for poor prognosis following thrombolysis in SAO patients, both of which have substantial predictive value.</p>","PeriodicalId":56009,"journal":{"name":"Risk Management and Healthcare Policy","volume":"18 ","pages":"915-922"},"PeriodicalIF":2.7000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928325/pdf/","citationCount":"0","resultStr":"{\"title\":\"Analysis of Risk Factors for Poor Prognosis Following Small Artery Occlusion or Lacunar Stroke: A Retrospective Cohort Study.\",\"authors\":\"Yan Shi, Yongtao Liu, Jingjing Sun, Bing Zhao, Qingfan Xie\",\"doi\":\"10.2147/RMHP.S482736\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the risk factors and predictive value for poor prognosis following small artery occlusion stroke (SAO) or lacunar stroke.</p><p><strong>Methods: </strong>A retrospective cohort of 100 SAO patients who received their first intravenous thrombolysis (IVT) treatment with alteplase between March 2019 and March 2021 was collected. Based on the modified Rankin Scale (mRS) score of <3 at 90 days post-admission, patients were divided into a good prognosis group (61 cases) and a poor prognosis group (39 cases) for comparative analysis.</p><p><strong>Results: </strong>In our retrospective cohort study of 100 SAO patients treated with IVT from March 2019 to March 2021, we found no significant differences in gender, age or BMI between the 61 patients with good prognosis and the 39 with poor prognosis, although smoking habits varied. Statistically differences were observed between the two groups in terms of time from onset to hospital admission for thrombolysis (48.59±20.14 vs 40.03±23.73 min, <i>t</i>=2.202, <i>P</i>=0.030), triglycerides (1.56±0.92 vs 1.20±0.68 mmol/L, <i>t</i>=2.069, <i>P</i>=0.041), and smoking prevalence (42.62% vs 20.51%, <i>χ<sup>2</sup></i> =5.183, <i>P</i>=0.023). Regression analysis indicated that shorter time from onset to hospital admission for thrombolysis (<i>OR</i>=0.978, 95% CI: 0.957-0.993) was a protective factor against poor prognosis post-thrombolysis in SAO patients, while a history of smoking (<i>OR</i>=2.881, 95% CI: 1.115-7.444) was a risk factor for poor prognosis post-thrombolysis. The area under the curve (AUC) for predicting poor prognosis post-thrombolysis in SAO patients based on time from onset to hospital admission was 0.662 (95% CI: 0.552-0.771), with a cutoff value of 36.5 min; the AUC for predicting poor prognosis based on smoking history was 0.614 (95% CI: 0.502-0.726).</p><p><strong>Conclusion: </strong>An extended duration from onset to hospital admission for thrombolysis and smoking are identified as significant risk factors for poor prognosis following thrombolysis in SAO patients, both of which have substantial predictive value.</p>\",\"PeriodicalId\":56009,\"journal\":{\"name\":\"Risk Management and Healthcare Policy\",\"volume\":\"18 \",\"pages\":\"915-922\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928325/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Risk Management and Healthcare Policy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/RMHP.S482736\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Risk Management and Healthcare Policy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/RMHP.S482736","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0

摘要

目的:探讨小动脉闭塞性脑卒中(SAO)或腔隙性脑卒中后不良预后的危险因素及预测价值。方法:收集2019年3月至2021年3月期间首次接受阿替普酶静脉溶栓(IVT)治疗的100例SAO患者的回顾性队列。我们对2019年3月至2021年3月100例接受IVT治疗的SAO患者进行回顾性队列研究,结果发现预后良好的61例患者与预后较差的39例患者在性别、年龄和BMI方面均无显著差异,但吸烟习惯存在差异。两组患者起病至入院溶栓时间(48.59±20.14 vs 40.03±23.73 min, t=2.202, P=0.030)、甘油三酯(1.56±0.92 vs 1.20±0.68 mmol/L, t=2.069, P=0.041)、吸烟率(42.62% vs 20.51%, χ2 =5.183, P=0.023)差异均有统计学意义。回归分析显示,起病至入院溶栓时间较短(OR=0.978, 95% CI: 0.957-0.993)是SAO患者溶栓后不良预后的保护因素,吸烟史(OR=2.881, 95% CI: 1.115-7.444)是溶栓后不良预后的危险因素。基于发病至入院时间预测SAO患者溶栓后不良预后的曲线下面积(AUC)为0.662 (95% CI: 0.552-0.771),截止值为36.5 min;基于吸烟史预测不良预后的AUC为0.614 (95% CI: 0.502 ~ 0.726)。结论:从发病到溶栓时间延长和吸烟是SAO患者溶栓后不良预后的重要危险因素,两者均具有重要的预测价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Risk Factors for Poor Prognosis Following Small Artery Occlusion or Lacunar Stroke: A Retrospective Cohort Study.

Objective: To investigate the risk factors and predictive value for poor prognosis following small artery occlusion stroke (SAO) or lacunar stroke.

Methods: A retrospective cohort of 100 SAO patients who received their first intravenous thrombolysis (IVT) treatment with alteplase between March 2019 and March 2021 was collected. Based on the modified Rankin Scale (mRS) score of <3 at 90 days post-admission, patients were divided into a good prognosis group (61 cases) and a poor prognosis group (39 cases) for comparative analysis.

Results: In our retrospective cohort study of 100 SAO patients treated with IVT from March 2019 to March 2021, we found no significant differences in gender, age or BMI between the 61 patients with good prognosis and the 39 with poor prognosis, although smoking habits varied. Statistically differences were observed between the two groups in terms of time from onset to hospital admission for thrombolysis (48.59±20.14 vs 40.03±23.73 min, t=2.202, P=0.030), triglycerides (1.56±0.92 vs 1.20±0.68 mmol/L, t=2.069, P=0.041), and smoking prevalence (42.62% vs 20.51%, χ2 =5.183, P=0.023). Regression analysis indicated that shorter time from onset to hospital admission for thrombolysis (OR=0.978, 95% CI: 0.957-0.993) was a protective factor against poor prognosis post-thrombolysis in SAO patients, while a history of smoking (OR=2.881, 95% CI: 1.115-7.444) was a risk factor for poor prognosis post-thrombolysis. The area under the curve (AUC) for predicting poor prognosis post-thrombolysis in SAO patients based on time from onset to hospital admission was 0.662 (95% CI: 0.552-0.771), with a cutoff value of 36.5 min; the AUC for predicting poor prognosis based on smoking history was 0.614 (95% CI: 0.502-0.726).

Conclusion: An extended duration from onset to hospital admission for thrombolysis and smoking are identified as significant risk factors for poor prognosis following thrombolysis in SAO patients, both of which have substantial predictive value.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Risk Management and Healthcare Policy
Risk Management and Healthcare Policy Medicine-Public Health, Environmental and Occupational Health
CiteScore
6.20
自引率
2.90%
发文量
242
审稿时长
16 weeks
期刊介绍: Risk Management and Healthcare Policy is an international, peer-reviewed, open access journal focusing on all aspects of public health, policy and preventative measures to promote good health and improve morbidity and mortality in the population. Specific topics covered in the journal include: Public and community health Policy and law Preventative and predictive healthcare Risk and hazard management Epidemiology, detection and screening Lifestyle and diet modification Vaccination and disease transmission/modification programs Health and safety and occupational health Healthcare services provision Health literacy and education Advertising and promotion of health issues Health economic evaluations and resource management Risk Management and Healthcare Policy focuses on human interventional and observational research. The journal welcomes submitted papers covering original research, clinical and epidemiological studies, reviews and evaluations, guidelines, expert opinion and commentary, and extended reports. Case reports will only be considered if they make a valuable and original contribution to the literature. The journal does not accept study protocols, animal-based or cell line-based studies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信