Emmanuel F Drabo, Jennifer L Wolff, Linda C Chyr, Julie Zissimopoulos, Bryan Lau
{"title":"2012-2019年国家健康与老龄化趋势研究（NHATS）中的主观认知障碍（SCI）和未来痴呆风险","authors":"Emmanuel F Drabo, Jennifer L Wolff, Linda C Chyr, Julie Zissimopoulos, Bryan Lau","doi":"10.1177/08982643241308450","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundSubjective cognitive impairment (SCI), assessed in national surveys, offers potential for dementia monitoring and early detection. However, its causal link to dementia risk remains unclear.ObjectiveTo evaluate whether SCI causally affects dementia risk in U.S. older adults (≥65 years), considering mortality as a competing risk.MethodsUsing data from 1622 dementia-free older adults in the National Health and Aging Trends Study (NHATS) during 2011-2019, we estimated total, direct, and separable effects of SCI on dementia and mortality risks.ResultsSCI was reported by 7.6% at baseline and associated with a twofold increased dementia risk over 8 years (RR: 1.95, 95% CI: 1.07-3.07) and lower mortality risk (RR: 0.31, 95% CI: 0.10-0.67). Direct effect analysis indicated a potential direct causal link between SCI and dementia.ConclusionsSCI predicts dementia onset and inversely affects mortality, highlighting the importance of early detection and precise analytic approaches.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":"37 3-4_suppl","pages":"76S-90S"},"PeriodicalIF":2.2000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Subjective Cognitive Impairment (SCI) and Future Dementia Risk in the National Health and Aging Trends Study (NHATS) During 2012-2019.\",\"authors\":\"Emmanuel F Drabo, Jennifer L Wolff, Linda C Chyr, Julie Zissimopoulos, Bryan Lau\",\"doi\":\"10.1177/08982643241308450\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>BackgroundSubjective cognitive impairment (SCI), assessed in national surveys, offers potential for dementia monitoring and early detection. However, its causal link to dementia risk remains unclear.ObjectiveTo evaluate whether SCI causally affects dementia risk in U.S. older adults (≥65 years), considering mortality as a competing risk.MethodsUsing data from 1622 dementia-free older adults in the National Health and Aging Trends Study (NHATS) during 2011-2019, we estimated total, direct, and separable effects of SCI on dementia and mortality risks.ResultsSCI was reported by 7.6% at baseline and associated with a twofold increased dementia risk over 8 years (RR: 1.95, 95% CI: 1.07-3.07) and lower mortality risk (RR: 0.31, 95% CI: 0.10-0.67). Direct effect analysis indicated a potential direct causal link between SCI and dementia.ConclusionsSCI predicts dementia onset and inversely affects mortality, highlighting the importance of early detection and precise analytic approaches.</p>\",\"PeriodicalId\":51385,\"journal\":{\"name\":\"Journal of Aging and Health\",\"volume\":\"37 3-4_suppl\",\"pages\":\"76S-90S\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Aging and Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/08982643241308450\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Aging and Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/08982643241308450","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"GERONTOLOGY","Score":null,"Total":0}
Subjective Cognitive Impairment (SCI) and Future Dementia Risk in the National Health and Aging Trends Study (NHATS) During 2012-2019.
BackgroundSubjective cognitive impairment (SCI), assessed in national surveys, offers potential for dementia monitoring and early detection. However, its causal link to dementia risk remains unclear.ObjectiveTo evaluate whether SCI causally affects dementia risk in U.S. older adults (≥65 years), considering mortality as a competing risk.MethodsUsing data from 1622 dementia-free older adults in the National Health and Aging Trends Study (NHATS) during 2011-2019, we estimated total, direct, and separable effects of SCI on dementia and mortality risks.ResultsSCI was reported by 7.6% at baseline and associated with a twofold increased dementia risk over 8 years (RR: 1.95, 95% CI: 1.07-3.07) and lower mortality risk (RR: 0.31, 95% CI: 0.10-0.67). Direct effect analysis indicated a potential direct causal link between SCI and dementia.ConclusionsSCI predicts dementia onset and inversely affects mortality, highlighting the importance of early detection and precise analytic approaches.
期刊介绍：
The Journal of Aging and Health is an interdisciplinary forum for the presentation of research findings and scholarly exchange in the area of aging and health. Manuscripts are sought that deal with social and behavioral factors related to health and aging. Disciplines represented include the behavioral and social sciences, public health, epidemiology, demography, health services research, nursing, social work, medicine, and related disciplines. Although preference is given to manuscripts presenting the findings of original research, review and methodological pieces will also be considered.
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