Study of the relationship between the level of proinflammatory cytokines and β2-microglobulin with indicators of changes in the functional status of the kidneys in diabetic nepropathy to determine the degrees of chronic renal failure.

Objective: Aim: The purpose of this study is to analyze the correlations of pro-inflammatory cytokines and β2-microglobulin with indicators of changes in the functional state of kidneys in patients with diabetic nephropathy, to determine different degrees of chronic renal failure.

Patients and methods: Materials and Methods: 80 patients with type 1 and type 2 diabetes, complicated by diabetic nephropathy, at different levels of the functional state of the kidneys were examined.

Results: Results: It has been shown that the level of tumor necrosis factor α (TNFα) in the blood of patients with diabetic nephropathy (DN) is increased already with sufficient kidney function, decreases with chronic renal failure (CRF) of the I degree and reaches maximum values with CRF of the II and III degrees. Which indicates the degree of progression of fibroplastic and sclerotic processes in the kidneys with DN. The level of interleukin-1α (IL-1α) in the blood of patients with DN begins to decrease with sufficient kidney function, increases with CRF of the II degree, but remains below the values of the control group and is minimal in patients with CRF of the III degree, which reflects a decrease in the intensity of the acute-phase inflammatory process in the development of CRF.

Conclusion: Conclusions: The development and progression of CRF is accompanied by an increase in the excretion of β2-microglobulin in the urine in parallel with changes in the cytokine profile in the blood.