外泌体miR-92a-3p作为子宫腺肌症的有希望的标记物和潜在的治疗靶点。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Wanqi Shao, Yayuan Yu, Jianzhang Wang, Zhiruo Qiu, Shuyan Mei, Tao Cheng, Yichen Chen, Weili Zhu, Xiuhui Li, Xuan Che
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引用次数: 0

摘要

本研究旨在阐明microRNA-92a-3p (miR-92a-3p)在子宫腺肌症发病机制中的作用。我们研究了来自异位病变的外泌体中发现的miR-92a-3p如何影响子宫内膜细胞、背根神经节(DRG)和人脐静脉内皮细胞(HUVECs)的行为,并探索了其作为非侵入性生物标志物的潜力。我们的研究结果显示,miR-92a-3p在异位腺肌病病变衍生的外泌体中显著上调。这种上调与异位子宫内膜细胞、DRG和HUVECs的迁移和侵袭增强相关。此外,本研究表明尿外泌体中miR-92a-3p水平与子宫腺肌症的临床症状之间存在显著相关性,表明其有潜力作为该疾病的非侵入性生物标志物。这项研究阐明了一个涉及miR-92a-3p的外泌体信号传导过程,该过程驱动病理性浸润和血管生成,从而促进子宫腺肌症的进展。我们的研究结果强调了在生物流体外泌体中上调的miR-92a-3p作为诊断和监测子宫腺肌症的有前途的非侵入性生物标志物,并揭示了改善临床管理的新靶点和策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exosomal miR-92a-3p serves as a promising marker and potential therapeutic target for adenomyosis.

This study aimed to elucidate the role of microRNA-92a-3p (miR-92a-3p) in the pathogenesis of adenomyosis. We examined how miR-92a-3p, found in exosomes derived from ectopic lesions, influences the behaviour of endometrial cells, dorsal root ganglion (DRG), and human umbilical vein endothelial cells (HUVECs) and explored its potential as a non-invasive biomarker. Our findings revealed that miR-92a-3p was significantly upregulated in exosomes derived from ectopic adenomyotic lesions. This upregulation correlated with enhanced migration and invasion of eutopic endometrial cells, DRG, and HUVECs. Furthermore, this study demonstrated a significant correlation between miR-92a-3p levels in urinary exosomes and the clinical symptoms of adenomyosis, suggesting its potential as a non-invasive biomarker for the disease. This study elucidated an exosomal signalling process involving miR-92a-3p that drives pathological infiltration and angiogenesis to promote adenomyosis progression. Our findings highlight upregulated miR-92a-3p in biofluid exosomes as a promising non-invasive biomarker for diagnosing and monitoring adenomyosis and unveil novel targets and strategies for improved clinical management.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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