An acute posterior multifocal placoid pigment epitheliopathy with presumed systemic lupus erythematosus etiology.

This case report describes a patient with acute posterior multifocal placoid pigment epitheliopathy, presumed to be the initial manifestation of systemic lupus erythematosus (SLE), who responded to oral immunotherapy. The clinical, hematological, serological, and imaging examinations were carried out on the 28-year-old female who presented with bilateral multifocal central creamy lesions. The imaging modalities' findings and the overall visual improvement led us to diagnose acute posterior multifocal placoid pigmented epitheliopathy. This is the second time SLE has been presented as acute posterior multifocal placoid pigmented epitheliopathy, and before declaring it is idiopathic, we must investigate it thoroughly.