Jingjing Luo, Yunen Lin, Ziyou Zeng, Haiyun Deng, Tao Li
{"title":"超声剪切波弹性成像评价乳腺癌新辅助化疗疗效的研究。","authors":"Jingjing Luo, Yunen Lin, Ziyou Zeng, Haiyun Deng, Tao Li","doi":"10.1002/jcu.23951","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify reliable quantitative parameters of ultrasonic shear wave elastography (SWE) that demonstrate advantages in assessing the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer by comparison to conventional ultrasound (US). This research also analyzed the associations between SWE parameters and tumor collagen fibers from post-NAC breast cancer lesions to explore the histological micro-mechanisms of stiffness change for breast cancer after NAC.</p><p><strong>Methods: </strong>Forty-Seven breast cancer lesions examined with US and SWE were eligible for enrollment from January 2021 to July 2023. The ultrasonic maximum diameter (D<sub>max</sub>), mean elastic value (E<sub>mean</sub>), maximum elastic value (E<sub>max</sub>), and minimum elastic value (E<sub>min</sub>) before and after NAC were determined. Receiver operating characteristic (ROC) curves were drawn to compare the diagnostic efficacy regarding the change rates of the above parameters. Additionally, correlation analyses were performed to examine the relationship between effective SWE quantitative parameters and collagen fibers after NAC.</p><p><strong>Results: </strong>Among the 47 breast cancer lesions, 24 lesions showed significant pathological responses, while the other 23 lesions exhibited that the pathological responses were nonsignificant. The area under the curve (AUC) of ΔE<sub>min</sub> was the lowest (ΔE<sub>min</sub>:0.466, ΔD<sub>max</sub>: 0.679, ΔE<sub>max</sub>: 0.803, and ΔE<sub>mean</sub>: 0.813). The collagen fiber category showed a significant positive correlation with E<sub>mean</sub> (r = 0.711) and E<sub>max</sub> (r = 0.669) after NAC. However, the collagen fiber content demonstrated no significant correlation with E<sub>mean</sub> or E<sub>max</sub> (p > 0.05).</p><p><strong>Conclusion: </strong>D<sub>max</sub>, E<sub>mean</sub>, and E<sub>max</sub> are valuable parameters for evaluating NAC efficacy, while Emin is not reliable. E<sub>mean</sub> and E<sub>max</sub> demonstrate similar efficacy, both superior to D<sub>max</sub>. The stiffness of post-NAC breast cancer lesions is predominantly related to the category of collagen fibers rather than their content.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research of Ultrasonic Shear Wave Elastography in Evaluating the Efficiency of Neoadjuvant Chemotherapy for Breast Cancer.\",\"authors\":\"Jingjing Luo, Yunen Lin, Ziyou Zeng, Haiyun Deng, Tao Li\",\"doi\":\"10.1002/jcu.23951\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to identify reliable quantitative parameters of ultrasonic shear wave elastography (SWE) that demonstrate advantages in assessing the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer by comparison to conventional ultrasound (US). This research also analyzed the associations between SWE parameters and tumor collagen fibers from post-NAC breast cancer lesions to explore the histological micro-mechanisms of stiffness change for breast cancer after NAC.</p><p><strong>Methods: </strong>Forty-Seven breast cancer lesions examined with US and SWE were eligible for enrollment from January 2021 to July 2023. The ultrasonic maximum diameter (D<sub>max</sub>), mean elastic value (E<sub>mean</sub>), maximum elastic value (E<sub>max</sub>), and minimum elastic value (E<sub>min</sub>) before and after NAC were determined. Receiver operating characteristic (ROC) curves were drawn to compare the diagnostic efficacy regarding the change rates of the above parameters. Additionally, correlation analyses were performed to examine the relationship between effective SWE quantitative parameters and collagen fibers after NAC.</p><p><strong>Results: </strong>Among the 47 breast cancer lesions, 24 lesions showed significant pathological responses, while the other 23 lesions exhibited that the pathological responses were nonsignificant. The area under the curve (AUC) of ΔE<sub>min</sub> was the lowest (ΔE<sub>min</sub>:0.466, ΔD<sub>max</sub>: 0.679, ΔE<sub>max</sub>: 0.803, and ΔE<sub>mean</sub>: 0.813). The collagen fiber category showed a significant positive correlation with E<sub>mean</sub> (r = 0.711) and E<sub>max</sub> (r = 0.669) after NAC. However, the collagen fiber content demonstrated no significant correlation with E<sub>mean</sub> or E<sub>max</sub> (p > 0.05).</p><p><strong>Conclusion: </strong>D<sub>max</sub>, E<sub>mean</sub>, and E<sub>max</sub> are valuable parameters for evaluating NAC efficacy, while Emin is not reliable. E<sub>mean</sub> and E<sub>max</sub> demonstrate similar efficacy, both superior to D<sub>max</sub>. The stiffness of post-NAC breast cancer lesions is predominantly related to the category of collagen fibers rather than their content.</p>\",\"PeriodicalId\":15386,\"journal\":{\"name\":\"Journal of Clinical Ultrasound\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-03-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Ultrasound\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jcu.23951\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ACOUSTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Ultrasound","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jcu.23951","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ACOUSTICS","Score":null,"Total":0}
Research of Ultrasonic Shear Wave Elastography in Evaluating the Efficiency of Neoadjuvant Chemotherapy for Breast Cancer.
Objective: This study aimed to identify reliable quantitative parameters of ultrasonic shear wave elastography (SWE) that demonstrate advantages in assessing the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer by comparison to conventional ultrasound (US). This research also analyzed the associations between SWE parameters and tumor collagen fibers from post-NAC breast cancer lesions to explore the histological micro-mechanisms of stiffness change for breast cancer after NAC.
Methods: Forty-Seven breast cancer lesions examined with US and SWE were eligible for enrollment from January 2021 to July 2023. The ultrasonic maximum diameter (Dmax), mean elastic value (Emean), maximum elastic value (Emax), and minimum elastic value (Emin) before and after NAC were determined. Receiver operating characteristic (ROC) curves were drawn to compare the diagnostic efficacy regarding the change rates of the above parameters. Additionally, correlation analyses were performed to examine the relationship between effective SWE quantitative parameters and collagen fibers after NAC.
Results: Among the 47 breast cancer lesions, 24 lesions showed significant pathological responses, while the other 23 lesions exhibited that the pathological responses were nonsignificant. The area under the curve (AUC) of ΔEmin was the lowest (ΔEmin:0.466, ΔDmax: 0.679, ΔEmax: 0.803, and ΔEmean: 0.813). The collagen fiber category showed a significant positive correlation with Emean (r = 0.711) and Emax (r = 0.669) after NAC. However, the collagen fiber content demonstrated no significant correlation with Emean or Emax (p > 0.05).
Conclusion: Dmax, Emean, and Emax are valuable parameters for evaluating NAC efficacy, while Emin is not reliable. Emean and Emax demonstrate similar efficacy, both superior to Dmax. The stiffness of post-NAC breast cancer lesions is predominantly related to the category of collagen fibers rather than their content.
期刊介绍：
The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography.
The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents.
JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.
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