中性粒细胞百分比-白蛋白比和改良格拉斯哥预后评分对脑卒中患者发生脑卒中相关肺炎风险的预测价值比较

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S504231

Zhu Tian, Yufeng Lin, Yang Song, Chi Zhang, Zhiyun Wang

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引用次数: 0

摘要

目的：探讨中性粒细胞百分比-白蛋白比（NPAR）和改良格拉斯哥预后评分（mGPS）对脑卒中患者卒中相关性肺炎（SAP）发生的预测价值。方法：我们招募2022年1月至2023年2月在天津市第一中心医院住院的脑卒中患者（18岁）进行回顾性队列研究。根据四分位数将NPAR分为四组：Q1(结果：我们的研究包括851例脑卒中患者。147例患者（17.27%）发生SAP。在考虑混杂因素后，我们观察到高NPAR与SAP发生显著正相关[(对于第三个四分位数：优势比(OR)=2.35, 95%可信区间（CI）： 1.01-5.47；第四个四分位数：OR=3.35, 95% CI: 1.44-7.77)]。此外，结果还表明mGPS 1 （OR=2.26, 95% CI: 1.25-4.08）和mGPS 2 （OR=7.37, 95% CI: 2.63-20.70）分别与SAP发生率增加有关。ROC分析表明，NPAR[曲线下面积(AUC)=0.729, 95% CI: 0.687-0.771]和mGPS （AUC=0.671, 95% CI: 0.627-0.716）对SAP的发生均具有较好的预测能力。结论：NPAR和mGPS均可作为评估脑卒中患者SAP风险的可靠生物标志物，其中NPAR对SAP的预测价值优于mGPS。

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Comparison of the Predictive Value of Neutrophil Percentage-to-Albumin Ratio and Modified Glasgow Prognostic Score for the Risk of Stroke-Associated Pneumonia Among Stroke Patients.

Objective: To assess the predicting value of neutrophil percentage-to-albumin ratio (NPAR) and modified Glasgow Prognostic Score (mGPS) for Stroke-Associated Pneumonia (SAP) occurrence among stroke patients.

Methods: We recruited stroke patients (aged 18 years) hospitalized at Tianjin First Central Hospital from January 2022 to February 2023 for this retrospective cohort study. NPAR was categorized into four groups by considering the quartiles: Q1 (<1.38), Q2 (≥1.38 and <1.62), Q3 (≥1.62 and <1.87), Q4 (≥1.87). SAP incident was the primary outcome in this study. Univariate and multivariate logistic regression models were employed to explore the association between NPAR, mGPS and SAP occurrence among individuals with stroke. Besides, we compared the predicting value of NPAR and mGPS for SAP occurrence by the receiver operating characteristic (ROC) curve.

Results: Our study encompassed 851 patients with stroke. One hundred and forty-seven patients (17.27%) developed SAP. After accounting for confounding factors, we observed significant positive association of high NPAR with SAP occurrence [(for the third quartile: odds ratio (OR)=2.35, 95% confidence interval (CI): 1.01-5.47; for the fourth quartile: OR=3.35, 95% CI: 1.44-7.77)]. Additionally, the results also indicated that mGPS 1 (OR=2.26, 95% CI: 1.25-4.08) and mGPS 2 (OR=7.37, 95% CI: 2.63-20.70) were related to the increased probability of SAP, respectively. ROC analysis demonstrated that both the NPAR [area under the curve (AUC)=0.729, 95% CI: 0.687-0.771] and mGPS (AUC=0.671, 95% CI: 0.627-0.716) exhibited good predictive power for SAP occurrence. Based on the DeLong test, the predictive value of NPAR for SAP may be significantly superior to that of mGPS (P<0.05).

Conclusion: Our findings suggest that both NPAR and mGPS serve as reliable biomarker for assessing SAP risk in stroke patients, with NPAR demonstrating superior predictive value for SAP compared to mGPS.

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.