腹内侧前额叶皮层中不同的神经元过程介导了雄性大鼠注意力负荷和尼古丁促进认知效应的变化。

IF 3 3区 医学 Q2 NEUROSCIENCES
Frontiers in Neural Circuits Pub Date : 2025-03-07 eCollection Date: 2025-01-01 DOI:10.3389/fncir.2025.1540975
Caroline Vouillac-Mendoza, Nathalie Biendon, Sandra Dovero, Karine Guillem
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引用次数: 0

摘要

前额叶皮层(PFC)在注意力中起着关键作用。特别是,腹内侧PFC (vmPFC)的神经元活动与提示呈现之前的准备注意期有关。然而,在这个准备阶段,vmPFC神经元的活动是否对任务需求的变化和尼古丁的促认知作用也很敏感,还有待研究。在这里,我们使用体内电生理学来记录大鼠在两种不同操作过程中的vmPFC神经元活动:一种是通过减少线索刺激持续时间(从1到0.5 s)来增加任务需求的任务操作,另一种是通过在会话前注射急性尼古丁(10 μg/ injj, i.v.)来进行药理学操作。我们发现,增加任务需求会降低注意力表现,vmPFC会促进神经元活动,但对伽马振荡没有影响。相比之下,尼古丁注射增加了注意力和伽马振荡,但几乎消除了vmPFC的相位预反应。总之,这些发现表明存在两个不同的神经元过程在不同的时间尺度上运作,并表明注意力的分配可以通过vmPFC内的多个神经元机制来实现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distinct neuronal processes in the ventromedial prefrontal cortex mediate changes in attention load and nicotine pro-cognitive effects in male rats.

The prefrontal cortex (PFC) plays a key role in attention. In particular, neuronal activity in the ventromedial PFC (vmPFC) has been implicated in the preparatory attentional period that immediately precedes cue presentation. However, whether vmPFC neuronal activity during this preparatory period is also sensitive to changes in task demand and to the pro-cognitive effects of nicotine remained to be investigated. Here, we used in vivo electrophysiology to record vmPFC neuronal activity in rats during two distinct manipulations: a task manipulation that increased task demand by reducing the cue stimulus duration (from 1 to 0.5 s), and a pharmacological manipulation by administrating an acute nicotine injection (10 μg/inj, i.v.) before the session. We found that increasing task demand decreased attentional performances and vmPFC precue neuronal activity, but had no effect on gamma oscillations. In contrast, nicotine injection increased attention and gamma oscillations, but almost abolished vmPFC phasic precue responses. Together, these findings indicate the existence of two distinct neuronal processes operating at different timescales and suggests that allocation of attention could be achieved through multiple neuronal mechanisms within the vmPFC.

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来源期刊
CiteScore
6.00
自引率
5.70%
发文量
135
审稿时长
4-8 weeks
期刊介绍: Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.
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