导致男性不育的遗传综合征:系统综述。

IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY
Lucille G Cheng, Sherry L Huang, Kathleen Hwang
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引用次数: 0

摘要

男性因素不育是一种多因素、复杂和日益常见的疾病,其中遗传因素更经常涉及。不仅遗传变异与男性不育表型之间的因果关系未得到充分研究,而且不同地理和种族群体中致病基因改变频率的差异也未得到充分研究。在男性不育症检查中,关于推荐的基因组检测的指导方针仍然不一致。我们目前的知识限制了我们的诊断能力,尽管在基因组测序和测试方面取得了进展,但男性不育症的病因仍然是大约40%的患者的特发性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic Syndromes Leading to Male Infertility: A Systematic Review.

Male-factor infertility is a multifactorial, complex, and increasingly common condition, of which genetic factors have more frequently been implicated in. Not only are the causal relationships between genetic variation and male infertility phenotypes understudied, but also the differences in frequency of disease-causing genetic alterations within different geographic and ethnic groups. Guidelines remain inconsistent as to recommended genomic testing during the male infertility workup. Our current fund of knowledge limits our diagnostic capability where the etiology of male infertility remains idiopathic in about 40% of patients, despite advances in genomic sequencing and testing.

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来源期刊
Fertility and sterility
Fertility and sterility 医学-妇产科学
CiteScore
11.30
自引率
6.00%
发文量
1446
审稿时长
31 days
期刊介绍: Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.
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