既往链球菌感染在成年强迫症患者中的作用:一项研究。

IF 3.4 3区 医学 Q2 CLINICAL NEUROLOGY
Donatella Marazziti, Stefania Palermo, Alessandro Arone, Manuel Glauco Carbone, Lucia Massa, Lara Foresi Crowther, Nicola Schulz Bizzozzero Crivelli, Riccardo Gurrieri, Francesco Weiss, Federico Mucci, Liliana Dell'Osso
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引用次数: 0

摘要

自身免疫过程在儿童和成年强迫症(OCD)患者中都有记载,与链球菌感染相关的儿童自身免疫神经精神疾病(PANDAS)代表了该模型的范例。鉴于现有信息有限,本研究旨在评估暴露于先前a组β-溶血性链球菌感染的成年强迫症患者的特征,以及一些外周炎症生物标志物。材料与方法:从247例成年强迫症门诊患者中招募抗链球菌溶血素O (ASO)滴度阳性的52例,按照DSM-5标准诊断,采用耶鲁-布朗强迫症量表进行评估。比较两组患者的临床特征。研究了不同参数之间可能存在的关系。结果:36例接受强迫症药物治疗的患者ASO滴度明显低于其他患者。中性粒细胞计数分别与“与强迫思想相关的痛苦”项目和患者的年龄呈正相关和负相关。淋巴细胞计数和叶酸水平在30名没有围产期损伤的受试者中较高。结论:这些结果似乎表明,ASO滴度阳性的强迫症受试者表现出慢性炎症状态,尽管没有症状或细菌感染的回忆,这可能与强迫症的发病和维持有关,免疫学改变与症状维度有关。他们还支持一些精神药物化合物可能具有抗炎作用的观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of previous streptococcal infections in adult patients with obsessive-compulsive disorder: a research study.

Introduction: Autoimmune processes have been documented in both childhood and adulthood patients with obsessive-compulsive disorder (OCD), with the pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) representing the paradigm of this model.Given the limited information available, the present study aimed at assessing the characteristics of adult patients with OCD exposed to a previous group A β-hemolytic Streptococcus infection, together with some peripheral inflammatory biomarkers.

Materials and methods: Fifty-two subjects displaying antistreptolysin O (ASO) titer positivity were recruited from a sample of 247 adult OCD outpatients, diagnosed according to DSM-5 criteria and assessed by the Yale-Brown Obsessive-Compulsive Scale. Their clinical features were assessed and compared. The possible relationships between the different parameters were also examined.

Results: Thirty-six subjects who were on medication for OCD showed significantly lower ASO titers than the other. The neutrophil count was positively and negatively related to, respectively, the "distress associated with obsessive thoughts" item and to the patients' age. The lymphocyte count and folic acid levels were higher in 30 subjects with no perinatal insults.

Conclusions: These results seem to suggest that OCD subjects with ASO titer-positivity show a chronic inflammatory state, in spite of no symptoms or recall of bacterial infections, that might be involved in both the onset and the maintenance of OCD, with immunological alterations being related to symptom dimension to be identified. They also support the notion of possible anti-inflammatory effects of some psychotropic compounds.

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来源期刊
CNS Spectrums
CNS Spectrums 医学-精神病学
CiteScore
6.20
自引率
6.10%
发文量
239
审稿时长
>12 weeks
期刊介绍: CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.
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