Zn/ h2o介导的2-（2-硝基苯）- 1h -苯并[d]咪唑与醛的串联还原环化合成5,6-二氢苯并[4,5]咪并[1,2-c]喹唑啉。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-03-19 DOI:10.1039/D4OB01976H

Xiaopeng Zhang, Qiuyang Pang, Zhenhua Guo, Zihua Yang and Guisheng Zhang

引用次数: 0

摘要

以2-（2-硝基苯）- 1h -苯并[d]咪唑和醛为原料，采用Zn/ h2o催化还原环化工艺，建立了一锅串联合成5,6-二氢苯并[4,5]咪唑[1,2-c]喹诺酮类化合物的方法，具有原料便宜易得、工艺简单、绿色环保、经济高效、产率高、产品种类多样等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Zn/H2O-mediated tandem reductive cyclization of 2-(2-nitrophenyl)-1H-benzo[d]imidazoles with aldehydes to synthesize 5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolines†

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Zn/H2O-mediated tandem reductive cyclization of 2-(2-nitrophenyl)-1H-benzo[d]imidazoles with aldehydes to synthesize 5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolines†

A one-pot tandem approach to synthesize 5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinolones has been developed from 2-(2-nitrophenyl)-1H-benzo[d]imidazoles and aldehydes via a Zn/H₂O-mediated reductive cyclization process, characterised by cheap and readily available raw materials, a simple, green, economical and efficient protocol, good product yields and product diversity.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.