A Highly Efficient Low-Cost Flexible Neural Probe for Scalable Mass Fabrication.

Neural probes capable of the precise recording and control of brain signals are essential tools for brain-computer interfaces and neuroscience research. However, conventional neural probes have not been widely adopted due to the high costs associated with semiconductor fabrication and complex packaging procedures. Herein, we present a breakthrough in this area in the form of a highly efficient flexible neural probe with a production cost of only 1.5 dollars per unit that can be mass-produced (1000 units within 3 days). The probe design is based on a standardized flexible printed circuit board (PCB) process that ensures large-scale producibility and minimizes device performance variation. The device features four independent neural probes that enable flexible targeting of multiple brain regions and a reusable interface PCB that minimizes packaging complexity. The neural signal recording performance of the fabricated probe is comparable to that of traditional silicon-based probes and is scalable with eight electrodes capable of simultaneous measurements. We anticipate that our innovative device will significantly improve the accessibility of neuroscience research.