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IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-03-25 DOI:10.1111/cns.70355

Chaofan Sui, Qihao Zhang, Kelly Gillen, Yian Gao, Nan Zhang, Mengmeng Feng, Haotian Xin, Changhu Liang, Lingfei Guo, Yi Wang

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引用次数: 0

摘要

目的本研究利用定量易感性图谱（QSM）探讨脑小血管病（CSVD）患者脑铁水平、情绪、认知和运动功能之间的关系。方法本研究共招募了 208 名受试者。通过自动均匀脑脊液零参考算法（MEDI+0）的形态学偶极子反转，从多回波GRE数据中计算出脑QSM图。应用多元线性回归分析探讨了影响 CSVD 患者大脑易感性的临床因素。研究了脑铁水平与运动功能之间的相关性分析和特定途径的中介效应。结果三组患者的MoCA评分、抑郁评分、五次重复坐立测试（5R-STS）时间以及尾状核和普鲁士门的易感性值均存在明显差异（P < 0.05，FDR校正）。年龄和糖尿病史对尾状核和普鲁曼的脑铁水平起着至关重要的作用，这可能会增加基底节的铁水平，与认知能力下降有关。值得注意的是，CSVD 受试者左侧尾状核和丘脑的易感性值与 5R-STS 时间呈正相关，焦虑对预测 CSVD 患者运动功能障碍与左侧丘脑铁水平之间存在显著的中介效应。结论年龄、糖尿病状况和焦虑可作为 CSVD 患者，尤其是认知和运动功能障碍患者的有效干预目标。较大的脑铁负荷可能是CSVD患者认知和运动功能障碍的定量成像标记。试验注册 ISRCTN20008650

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Association of Increased Brain Iron Levels With Anxiety and Motor Dysfunction in Cerebral Small Vessel Disease

查看原文本刊更多论文

Association of Increased Brain Iron Levels With Anxiety and Motor Dysfunction in Cerebral Small Vessel Disease

Aims

This study explored the relationships between brain iron levels, emotion, and cognitive and motor function in cerebral small vessel disease (CSVD) patients using quantitative susceptibility mapping (QSM).

Methods

A total of 208 subjects were enrolled in this study. A brain QSM map was calculated from multiecho GRE data via morphology-enabled dipole inversion with an automatic uniform cerebrospinal fluid zero reference algorithm (MEDI+0). Multiple linear regression analysis was applied to explore the clinical factors influencing cerebral susceptibility in CSVD patients. Correlation analysis and pathway-specific mediation effects between brain iron levels and motor function were investigated.

Results

There were significant differences in the MoCA scores, depression scores, five-repetition sit-to-stand test (5R-STS) time, and susceptibility values of the caudate nucleus and putamen among the three groups (p < 0.05, FDR correction). Age and history of diabetes played crucial roles in brain iron levels in the caudate nucleus and putamen, which may increase iron levels in the basal ganglia, associated with cognitive decline. Notably, the susceptibility values of the left caudate nucleus and putamen were positively correlated with the 5R-STS time in CSVD subjects, and there were significant mediating effects of anxiety on the prediction of motor dysfunction with respect to iron levels in the left putamen in CSVD patients.

Conclusion

Age, diabetes status, and anxiety may serve as effective intervention targets for individuals with CSVD, especially individuals with cognitive and motor dysfunction. A greater brain iron burden may be a quantitative imaging marker of cognitive and motor dysfunction in CSVD patients.

Trial Registration

ISRCTN20008650

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.