Entropy generation (EG) is intrinsically linked with irreversibilities present within a thermodynamical system, signifying energy losses, mainly in the context of fluid friction and heat transfer. In systems characterized by nanofluid flow, such as those utilized in cooling applications, microelectronics, and heat exchangers, the reduction of EG is essential for augmenting energy efficiency by alleviating these losses. In this communication, mixed convection flow of Sutterby nanoliquid by a porous stretched sheet along with irreversibility is analyzed. The momentum equation is reported by taking mixed convection and magnetic field impacts. Dissipation, Lorentz force, and radiation influences are taken in the development of heat transport relation. The expression for concentration is described by taking the chemical reaction effect. Thermodynamics second law is employed to describe entropy. The partial differential equations (PDEs) indicating the flow phenomenon are altered into self-similar form via transformations. The NDSolve function of Mathematica package is availed to solve the self-similar system. The impact of sundry variables on concentration, velocity, Bejan quantity, irreversibility, and thermal field is analyzed graphically. Engineering quantities are discussed numerically. The results reveal that the velocity profile upsurges for higher thermal buoyancy parameter, while it decays for raising magnetic variable. For raising values of Eckert number temperature upsurges, while it decays for an upturn in Prandtl number. Entropy is more for superior values of diffusion and radiation variables.