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IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases Pub Date : 2025-03-22 DOI:10.1016/j.ttbdis.2025.102459

Mathilde Ørbæk , Fernando Gonzalez-Ortiz , Rosa M.M. Gynthersen , Åse Bengaard Andersen , Kubra Tan , Ulf Andreasson , Kaj Blennow , Helene Mens , Henrik Zetterberg , Anne-Mette Lebech

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引用次数: 0

摘要

背景神经源性脑病（NB）可靠的血液生物标志物尚未确定。本研究调查了NB患者随访6个月期间神经元损伤标志物胶质纤维酸性蛋白（GFAP）和脑源性tau（BD-tau）的水平。方法一项回顾性纵向队列研究，包括2018年至2020年期间在Rigshospitalet传染病部登记的成年NB患者在诊断时和诊断后大约3个月和6个月收集的血浆。BD-tau浓度在内部使用单分子阵列（Simoa）HD-X平台进行测量，而GFAP浓度则在同一平台上使用GFAP发现试剂盒进行评估。采用非结构化协方差模式的线性混合模型对生物标志物浓度的变化进行分析，随访作为分类固定效应。在整个研究期间，GFAP 和 BD-tau 水平的变化极小。与完全康复者相比，症状持续存在的患者在确诊时的 GFAP 浓度高出 55%，但这一差异并无统计学意义（p = 0.09）。结论这项纵向研究并未发现 BD-tau 或 GFAP 是监测 NB 治疗反应或预测疗效的有效血液生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Plasma levels of the neuron damage markers brain-derived tau and glial fibrillary acidic protein in Lyme neuroborreliosis: A longitudinal study

Background

A reliable blood biomarker for neuroborreliosis (NB) has yet to be identified. This study investigated levels of neuron damage markers glial fibrillary acidic protein (GFAP) and brain-derived tau (BD-tau) over six months of follow-up in patients with NB. The aim was to evaluate the potential of these biomarkers for monitoring treatment response and prognostic purposes.

Methods

A retrospective longitudinal cohort study including plasma collected at diagnosis and approximately three- and six-months post diagnosis from adult NB patients enrolled at the Department of Infectious Diseases, Rigshospitalet between 2018 and 2020.

BD-tau concentrations were measured in-house using the Single Molecule Array (Simoa) HD-X platform, while GFAP concentrations were assessed on the same platform utilizing the GFAP Discovery Kit. Changes in biomarker concentrations were analyzed using linear mixed models with an unstructured covariance pattern, with follow-up included as a categorical fixed effect.

Results

A total of 23 patients (median age: 63 years; male/female ratio: 16/7) with 56 plasma samples were analyzed; 12 patients had complete samples. GFAP and BD-tau levels showed minimal variation throughout the study period. Patients with persistent symptoms had GFAP concentrations that were 55 % higher at diagnosis compared to those who fully recovered, though this difference was not statistically significant (p = 0.09). No significant associations were observed between biomarker levels and treatment response or long-term outcomes.

Conclusions

This longitudinal study did not find BD-tau or GFAP to be effective blood biomarkers for monitoring treatment response or predicting outcomes in NB.

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来源期刊

Ticks and Tick-borne Diseases INFECTIOUS DISEASES-MICROBIOLOGY

CiteScore

6.90

自引率

12.50%

发文量

185

审稿时长

6-12 weeks

期刊介绍： Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials. The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.