欧洲癌症研究与治疗组织放射肿瘤学科学委员会的2024年科学状况报告

IF 7.6 1区医学 Q1 ONCOLOGY

European Journal of Cancer Pub Date : 2025-03-03 DOI:10.1016/j.ejca.2025.115334

Daniel Portik , Denis Lacombe , Corinne Faivre-Finn , Vérane Achard , Nicolaus Andratschke , Dora Correia , Mateusz Spalek , Matthias Guckenberger , Piet Ost , Felix Ehret

{"title":"欧洲癌症研究与治疗组织放射肿瘤学科学委员会的2024年科学状况报告","authors":"Daniel Portik , Denis Lacombe , Corinne Faivre-Finn , Vérane Achard , Nicolaus Andratschke , Dora Correia , Mateusz Spalek , Matthias Guckenberger , Piet Ost , Felix Ehret","doi":"10.1016/j.ejca.2025.115334","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Radiotherapy (RT) is a central pillar of a multimodal cancer treatment approach. The ongoing advances in the fields of RT, imaging technologies, cancer biology, and others yield the potential to refine the use of RT. The European Organisation for Research and Treatment of Cancer (EORTC) hosted a dedicated workshop to identify and prioritize key research questions and to define future RT-based treatment strategies to improve the survival and quality of life of cancer patients.</div></div><div><h3>Methods</h3><div>An initial call for relevant RT research topics led to the formation of workgroups to develop these into new clinical research proposals and projects. The EORTC Radiation Oncology Scientific Council (ROSC) State of Science workshop was held in Brussels, Belgium, in February 2024, bringing together EORTC members and international stakeholders to connect and work on the proposals.</div></div><div><h3>Results</h3><div>Four topics of interest were identified: I) De-escalation of RT, minimizing toxicity while maintaining patients’ quality of life, II) Technology-driven RT utilizing advances in treatment techniques, such as spatially fractionated RT to improve outcomes in patients with bulky disease and localized high tumor burden, III) Biology-driven RT, integrating the rapid advances in cancer biology and functional imaging to guide and personalize RT, and IV) New indications adding value and expanding the use of RT.</div></div><div><h3>Conclusion</h3><div>The EORTC ROSC State of Science workshop prioritized clinical questions to be addressed in prospective clinical research projects to advance RT care and improve patient outcomes.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"220 ","pages":"Article 115334"},"PeriodicalIF":7.6000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The 2024 State of Science report from the European Organisation for Research and Treatment of Cancer’s Radiation Oncology Scientific Council\",\"authors\":\"Daniel Portik , Denis Lacombe , Corinne Faivre-Finn , Vérane Achard , Nicolaus Andratschke , Dora Correia , Mateusz Spalek , Matthias Guckenberger , Piet Ost , Felix Ehret\",\"doi\":\"10.1016/j.ejca.2025.115334\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Radiotherapy (RT) is a central pillar of a multimodal cancer treatment approach. The ongoing advances in the fields of RT, imaging technologies, cancer biology, and others yield the potential to refine the use of RT. The European Organisation for Research and Treatment of Cancer (EORTC) hosted a dedicated workshop to identify and prioritize key research questions and to define future RT-based treatment strategies to improve the survival and quality of life of cancer patients.</div></div><div><h3>Methods</h3><div>An initial call for relevant RT research topics led to the formation of workgroups to develop these into new clinical research proposals and projects. The EORTC Radiation Oncology Scientific Council (ROSC) State of Science workshop was held in Brussels, Belgium, in February 2024, bringing together EORTC members and international stakeholders to connect and work on the proposals.</div></div><div><h3>Results</h3><div>Four topics of interest were identified: I) De-escalation of RT, minimizing toxicity while maintaining patients’ quality of life, II) Technology-driven RT utilizing advances in treatment techniques, such as spatially fractionated RT to improve outcomes in patients with bulky disease and localized high tumor burden, III) Biology-driven RT, integrating the rapid advances in cancer biology and functional imaging to guide and personalize RT, and IV) New indications adding value and expanding the use of RT.</div></div><div><h3>Conclusion</h3><div>The EORTC ROSC State of Science workshop prioritized clinical questions to be addressed in prospective clinical research projects to advance RT care and improve patient outcomes.</div></div>\",\"PeriodicalId\":11980,\"journal\":{\"name\":\"European Journal of Cancer\",\"volume\":\"220 \",\"pages\":\"Article 115334\"},\"PeriodicalIF\":7.6000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0959804925001157\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959804925001157","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

放射治疗（RT）是多模式癌症治疗方法的核心支柱。放射治疗、成像技术、癌症生物学和其他领域的不断进步，产生了改进放射治疗使用的潜力。欧洲癌症研究和治疗组织（EORTC）主办了一个专门的研讨会，以确定和优先考虑关键研究问题，并确定未来基于放射治疗的治疗策略，以提高癌症患者的生存率和生活质量。方法通过对相关RT研究课题的初步征集，形成工作组，将其发展成新的临床研究方案和项目。EORTC放射肿瘤学科学委员会（ROSC）科学状况研讨会于2024年2月在比利时布鲁塞尔举行，汇集了EORTC成员和国际利益相关者，就提案进行联系和工作。结果确定了四个感兴趣的主题：1)减低放射治疗的升级，在保持患者生活质量的同时将毒性降到最低；2)技术驱动的放射治疗，利用先进的治疗技术，如空间分割放射治疗，改善疾病体积大、局部肿瘤负担高的患者的预后；3)生物学驱动的放射治疗，结合癌症生物学和功能影像学的快速进展，指导和个性化放射治疗。结论EORTC ROSC科学状况研讨会优先考虑了前瞻性临床研究项目中需要解决的临床问题，以推进RT治疗并改善患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The 2024 State of Science report from the European Organisation for Research and Treatment of Cancer’s Radiation Oncology Scientific Council

Background

Radiotherapy (RT) is a central pillar of a multimodal cancer treatment approach. The ongoing advances in the fields of RT, imaging technologies, cancer biology, and others yield the potential to refine the use of RT. The European Organisation for Research and Treatment of Cancer (EORTC) hosted a dedicated workshop to identify and prioritize key research questions and to define future RT-based treatment strategies to improve the survival and quality of life of cancer patients.

Methods

An initial call for relevant RT research topics led to the formation of workgroups to develop these into new clinical research proposals and projects. The EORTC Radiation Oncology Scientific Council (ROSC) State of Science workshop was held in Brussels, Belgium, in February 2024, bringing together EORTC members and international stakeholders to connect and work on the proposals.

Results

Four topics of interest were identified: I) De-escalation of RT, minimizing toxicity while maintaining patients’ quality of life, II) Technology-driven RT utilizing advances in treatment techniques, such as spatially fractionated RT to improve outcomes in patients with bulky disease and localized high tumor burden, III) Biology-driven RT, integrating the rapid advances in cancer biology and functional imaging to guide and personalize RT, and IV) New indications adding value and expanding the use of RT.

Conclusion

The EORTC ROSC State of Science workshop prioritized clinical questions to be addressed in prospective clinical research projects to advance RT care and improve patient outcomes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

European Journal of Cancer 医学-肿瘤学

CiteScore

11.50

自引率

4.80%

发文量

953

审稿时长

23 days

期刊介绍： The European Journal of Cancer (EJC) serves as a comprehensive platform integrating preclinical, digital, translational, and clinical research across the spectrum of cancer. From epidemiology, carcinogenesis, and biology to groundbreaking innovations in cancer treatment and patient care, the journal covers a wide array of topics. We publish original research, reviews, previews, editorial comments, and correspondence, fostering dialogue and advancement in the fight against cancer. Join us in our mission to drive progress and improve outcomes in cancer research and patient care.