克林格勒（Klingler）脑解剖技术：回顾其原始程序和技术考虑

Q3 Medicine

Translational Research in Anatomy Pub Date : 2025-03-20 DOI:10.1016/j.tria.2025.100393

Andrzej Żytkowski , Jakub Dębski , Stanisław Orkisz

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引用次数: 0

摘要

Klingler的脑解剖技术最初是由Ludwig Klingler于1935年提出的，可以被认为是研究人脑白质束结构组织的有用研究手段。该方法涉及冷冻福尔马林固定的脑组织，这有助于纤维束的分离，使其成为神经解剖学教育和大脑连接研究的重要工具。目的考虑到该技术在研究和神经外科训练中的实际意义，本文旨在回顾Klingler方法的原始方法，分析近年来引入的关键修改，并评估其在当代解剖学和神经影像学研究中的意义。结论Klingler纤维解剖技术仍然是神经解剖学研究的基石，特别是与现代成像技术如神经束造影相结合。它能够揭示白质纤维的三维结构，巩固了它在解剖学教育和神经外科计划中的作用。

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The Klingler's brain dissection technique: Review of the original procedure and technical considerations

Background

The Klingler's brain dissection technique, originally introduced by Ludwig Klingler in 1935, can be considered an useful research toll for investigating the structural organization of white matter tracts in the human brain. The method involves freezing formalin-fixed brain tissue, which facilitates the separation of fiber tracts, making it a crucial tool for both neuroanatomical education and research on brain connectivity.

Aim

Given the practical relevance of this technique in both research and neurosurgical training, this review aims to recall the original Klingler's method, analyze key modifications introduced in recent years, and evaluate its significance in contemporary anatomical and neuroimaging research.

Conclusions

The Klingler's fiber dissection technique remains a cornerstone of neuroanatomical research, particularly in combination with modern imaging techniques such as tractography. Its ability to reveal the three-dimensional architecture of white matter fibers has solidified its role in both anatomical education and neurosurgical planning.

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来源期刊

Translational Research in Anatomy Medicine-Anatomy

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Translational Research in Anatomy is an international peer-reviewed and open access journal that publishes high-quality original papers. Focusing on translational research, the journal aims to disseminate the knowledge that is gained in the basic science of anatomy and to apply it to the diagnosis and treatment of human pathology in order to improve individual patient well-being. Topics published in Translational Research in Anatomy include anatomy in all of its aspects, especially those that have application to other scientific disciplines including the health sciences: • gross anatomy • neuroanatomy • histology • immunohistochemistry • comparative anatomy • embryology • molecular biology • microscopic anatomy • forensics • imaging/radiology • medical education Priority will be given to studies that clearly articulate their relevance to the broader aspects of anatomy and how they can impact patient care.Strengthening the ties between morphological research and medicine will foster collaboration between anatomists and physicians. Therefore, Translational Research in Anatomy will serve as a platform for communication and understanding between the disciplines of anatomy and medicine and will aid in the dissemination of anatomical research. The journal accepts the following article types: 1. Review articles 2. Original research papers 3. New state-of-the-art methods of research in the field of anatomy including imaging, dissection methods, medical devices and quantitation 4. Education papers (teaching technologies/methods in medical education in anatomy) 5. Commentaries 6. Letters to the Editor 7. Selected conference papers 8. Case Reports