约旦人乳头瘤病毒——650例的选择性研究

IF 1.5 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-03-03 DOI:10.1016/j.ijregi.2025.100620

Abeer W. Annab , Isam M. Lataifeh , Yahia F. Dajani

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引用次数: 0

摘要

目的通过对2011-2023年约旦安曼社区妇科门诊随机抽取的650例样本进行分析，了解人类乳头瘤病毒（HPV）在约旦安曼社区的发生情况。研究结果（包括随访病例）与该地区内外报告的结果进行了比较。方法本研究采用液体细胞学技术。应用逆转录-聚合酶链式反应机对妇科门诊样本进行HPV基因分型；接下来，一位病理学顾问报告了相应的ThinPrep幻灯片。如果感染是单一、多重或混合HR-HPV与LR-HPV，则将阳性病例分层为高风险或低风险（HR-HPV或LR-HPV）基因型。分析了安曼社区HPV的数量、年龄分布和高峰发病率。结果居住在安曼的644名女性和6名男性（丈夫）均来自妇科诊所，591名当地人中有152人感染HPV(25.7%)， 59名外籍人士中有19人感染HPV（23.2%）。ⅰ组单发感染106例，双发感染38例，三发感染7例，四发感染1例；152例中有114例（75%）为HR-HPV；15例（9.9%）合并HR和LR-HPV。II组单感染15例，双感染3例，三联感染1例；II组59例中有15例（79%）为HR-HPV， 3例（15.8%）为混合型，1例为LR-HPV。HR-HPV和LR-HPV最常见的基因型分别为16型和11型。HPV的发病率发生在30-44岁的约旦人和25-49岁的外籍人士。宫颈涂片结果异常，高级别和低级别瘤变与HR-HPV基因型有关。61人中22人（36%）HPV转化为阴性，平均随访（FU） 2.8年，4人（6.6%）HPV转化为阳性，平均FU为1.2年。结论一项局限于约旦安曼的选择性研究表明，宫颈HPV，特别是HR-HPV感染影响约旦安曼居民，宫颈癌在15-44岁妇女中排名第10位。关于发病率的任何推断都有待推广到约旦的其他城市和农村地区。HR-HPV基因型的发生和FU数据证明了促进HPV疫苗接种计划以抑制宫颈癌。

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Human Papillomavirus in Jordan—A selective study of 650 cases

Objectives

To study the occurrence of Human Papillomavirus (HPV) in the community of Amman, Jordan through analyzing 650 samples randomly referred from community-based gynecology clinics during the years 2011-2023. Findings, including follow-up cases, were compared with those reported from within and outside this region.

Methods

This study used a liquid-based cytology technique. Samples from gynecology clinics underwent HPV genotyping by reverse transcription-polymerase chain reaction machine; next, a consultant pathologist reported on corresponding ThinPrep slides. Positive cases were stratified into high- or low-risk (HR-HPV or LR-HPV) genotypes, if the infection was single, multiple, or mixed HR-HPV with LR-HPV. Numbers, age distribution, and peak incidence of HPV in an Amman community were analyzed.

Results

A total of 644 women and six men (husbands) resident in Amman, all from gynecology clinics, showed HPV infection in 152 of 591 natives group I (25.7%), and 19 of 59 expatriates group II (23.2%). Group I showed 106 single, 38 double, seven triple, and one quadruple infection; 114 of 152 (75%) were HR-HPV; and 15 (9.9%) had mixed HR and LR-HPV. Group II showed 15 single, three double, and one triple infection; 15 of 59 (79%) in group II were HR-HPV, three (15.8%) mixed, and one LR-HPV. The most frequently found genotypes were 16 and 11 for HR-HPV and LR-HPV, respectively. Incidence of HPV occurred during ages 30-44 years in Jordanians and 25-49 years in expatriates. Abnormal cervical smear results with high- and low-grade neoplasia were seen in association with HR-HPV genotypes. HPV converted to negative in 22 of 61 (36%), average follow-up (FU) 2.8 years, and to positive in four (6.6%), 1.2-year average FU.

Conclusions

A selective study limited to Amman, Jordan indicates that cervical HPV, particularly HR-HPV infection, affects residents of Amman, Jordan, in whom cervical cancer ranks 10^th in women 15-44 years old. Any extrapolation on incidence rates awaits extension into other cities and rural zones of Jordan. Occurrence of HR-HPV genotypes and FU data justify promoting HPV vaccination programs to curb cervical cancer.

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来源期刊

IJID regions Infectious Diseases

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

64 days