双功能有机催化剂催化5-吡唑酮酮酮的溶剂控制化学选择性不对称加氢过氧化和羟基化的环境

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-03-11 DOI:10.1021/acsomega.4c1060810.1021/acsomega.4c10608

Xiangfeng Lin, Bo Long, Hanhui Lei*, Terence Xiaoteng Liu* and Zhanhui Yuan*,

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引用次数: 0

摘要

化学选择性在有机合成中经常引起人们的极大关注，它是用相同的底物生产各种功能化产物的主要策略。利用酸碱双功能手性方酰胺作为有机催化剂，首次实现了5-吡唑酮酮酮的溶剂控制化学选择性不对称加氢过氧化和羟基化反应，获得了一系列具有高立体选择性（高达90% ee）的加氢过氧化和羟基化对映体富集产物。

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Environment of Solvent-Controlled Chemoselective Asymmetric Hydroperoxidation and Hydroxylation of 5-Pyrazolone Ketimines Catalyzed by Bifunctional Organocatalysts

Chemoselectivity often garners significant attention in organic synthesis, serving as a primary strategy for producing a variety of functionalized products from the same substrate. The first environment of solvent-controlled chemoselective asymmetric hydroperoxidation and hydroxylation of 5-pyrazolone ketimines has been achieved, using an acid–base bifunctional chiral squaramide as the organocatalyst, affording a range of enantioenriched products of hydroperoxidation and hydroxylation with high stereoselectivities (up to 90% ee).

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.