钴催化芳香烯烃的对映选择性氢三氟甲氧基化

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-03-24 DOI:10.1002/anie.202501680

Yafeng Si, Yuntao Liu, Fan Zhou, Lei Fang, Kang Wu, Yu-Xin Luan, Li Chen, pingping tang

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引用次数: 0

摘要

光学纯苄基三氟甲氧基（OCF3）化合物的构建仍然面临挑战，因为对映体选择性控制有限，或者只有两个先前的报道需要含有OCF3的底物。在此，我们开发了一个salen - Co催化的对映选择性氢化三氟甲基甲氧基化反应，涉及芳烃和三氟甲基芳基磺酸盐（TFMS）。该方法有效地生产了一系列手性三氟甲氧基苄基化合物，其对映体过量范围为75%至99%。

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Cobalt‐Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes

The construction of optically pure benzyl trifluoromethoxy (OCF3) compounds continues to present challenges, due to limited enantioselectivity‐control or the necessity for OCF3‐containing substrates of the only two previous reports. Herein, we have developed a salen‐Co‐catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.