四唑和羧酸之间的可见光催化偶联用于生物分子标记

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-03-24 DOI:10.1039/d4cc04452e

Takuro Matsuoka , Ryosuke Takasaki , Hiroki Akiba , Kosuke Ogata , Akira Hattori , Norihito Arichi , Hideaki Kakeya , Sho Yamasaki , Yasushi Ishihama , Hiroaki Ohno , Shinsuke Inuki

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引用次数: 0

摘要

光催化生物分子标记作为一种分析生物现象的基础技术正受到越来越多的关注。然而，与生理条件相容的光催化反应仍然有限。在这里，我们提出了二芳基四唑的光催化反应，以产生腈亚胺，它很容易与羧酸在水环境中偶联。该反应用于依赖光催化剂的蛋白质和细胞的标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling†

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Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling†

Photocatalytic biomolecular labelling is gaining attention as a foundational technique for analyzing biological phenomena. However, photocatalytic reactions compatible with physiological conditions remain limited. Here, we present a photocatalytic reaction of diaryltetrazoles to generate nitrile imines, which readily couple with carboxylic acids in aqueous environments. This reaction is applied for photocatalyst-dependent labelling of proteins and cells.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.