实验性诱导兔凸轮-股髋臼撞击畸形模型的统计形状建模:研究髋关节疾病机制的平台

Deniz C. Ince, Tomoyuki Kamenaga, Kenichi Kikuchi, John C. Clohisy, Regis J. O’Keefe, Catherine Yuh, Markus A. Wimmer, Steven P. Mell, Cecilia Pascual-Garrido
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引用次数: 0

摘要

背景:股髋臼撞击(FAI)是年轻人髋关节疼痛的一个常见决定因素,也是骨关节炎(OA)后续发展的一个确定的危险因素。髋关节骨关节炎继发于FAI的机制尚不清楚。小动物模型是理解疾病机制和开发介入治疗的关键转化工具。Kamenaga及其同事提出了一种新的动物模型来模拟cam-FAI;然而,诱导畸形的三维形态尚未客观研究。目的:利用统计形状建模定量描述诱导的股骨近端头颈畸形,以验证该动物模型作为人类cam-FAI的转化模型的必要步骤。研究设计:实验室对照研究。方法:取6周龄未成熟新西兰大白兔13只,右股骨物理损伤,左股骨作为对照。至少在损伤后4周对股骨进行显微计算机断层扫描。三维重建排列并进行统计形状建模,在每个股骨上放置2048个颗粒。使用Hotelling T检验计算和分析平均形状的差异。主成分分析用于描述形状变化,并行分析用于确定统计显著模态。结果:Hotelling t2检验显示cam-FAI与对照平均形状有显著差异(P <;. 01)。cam-FAI平均形状在前外侧头颈连接处比对照平均值最大突出0.8 mm,在股骨头颈连接处的前上侧面和前后中线处持续突出0.6至0.8 mm。在同一区域,单个cam-FAI股骨与平均对照股骨之间的最大偏差在0.1至1.6 mm之间。前6个模态解释了92.1%的累积变异,前13个模态具有统计学意义,证实了畸形。结论:该模型导致头颈凸轮畸形与人凸轮- fai相似。临床意义:该动物模型产生了类似于人类FAI观察到的凸轮型畸形,有助于验证该模型作为研究髋关节FAI OA机制和开发未来该疾病介入治疗的平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Statistical Shape Modeling of an Experimental, Induced Cam–Femoroacetabular Impingement Deformity in a Rabbit Model: A Platform to Study Mechanism of Hip Disease
Background: Femoroacetabular impingement (FAI) is a common determinant of hip pain in young adults and an established risk factor in the subsequent development of osteoarthritis (OA). The mechanism of hip OA secondary to FAI is unknown. Small-animal models are critical translational tools to understand mechanisms of disease and develop interventional therapies. Kamenaga and colleagues proposed a novel animal model to mimic cam-FAI; however, 3D morphology of the induced deformity has not been objectively investigated. Purpose: To use statistical shape modeling to quantitatively describe the induced proximal femoral head-neck deformity in order to take the necessary step in validating this animal model as a translational model for human cam-FAI. Study Design: Controlled laboratory study. Methods: Six-week-old immature New Zealand White rabbits (n = 13) were subject to right femur physis injury, with left femurs serving as controls. Micro–computed tomography images of femurs were taken at minimum 4 weeks after injury. 3D reconstructions were aligned and underwent statistical shape modeling with 2048 particles placed on each femur. Differences between mean shapes were calculated and analyzed using the Hotelling T 2 test. Principal component analysis was used to describe shape variation, and parallel analysis was used to determine the statistically significant modes. Results: Hotelling T 2 test demonstrated significant differences between cam-FAI and control mean shapes ( P < .01). The cam-FAI mean shape protruded above the control mean by a maximum of 0.8 mm in the anterolateral head-neck junction with sustained protrusions of ~0.6 to 0.8 mm over the anterosuperior aspect and anteroposterior midline of the femoral head-neck junction. Maximum deviations between individual cam-FAI femurs and the mean control femur ranged between 0.1 and 1.6 mm in the same region. The first 6 modes explained 92.1% of the cumulative variation, and the first 13 modes were statistically significant, confirming the deformity. Conclusion: The proposed model resulted in a head-neck cam deformity similar to human cam-FAI. Clinical Relevance: This proposed animal model creates a cam-type deformity similar to that observed in human FAI, helping validate the model as a platform to study mechanisms of hip FAI OA and develop future interventional therapies for this disease.
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